Associations between comorbidities and annual incidence plus frequency of asthma exacerbation hospitalisation during the past year: data from CARN study
单位：[1]Department of Pulmonary and Critical Care Medicine, China-Japan FriendshipHospital, Beijing 100029, China[2]Department of Respiration, Shanghai CentralHospital, Shanghai, China[3]Department of Respiration, Xinqiao Hospital, ThirdMilitary Medical University, Chongqing, China[4]Department of Pulmonaryand Critical Care Medicine, The First Affiliated Hospital of Nanjing MedicalUniversity, Nanjing, China[5]Department of Respiration, Nanfang Hospital,Guangzhou, China[6]Department of Respiratory Diseases, General Hospitalof Shenyang Military Command, Shenyang, China[7]Department of Respiration,The First Affiliated Hospital of Fujian Medical University, Fuzhou, China[8]Department of Respiration, The First Affiliated Hospital of Zhejiang UniversitySchool of Medicine, Hangzhou, China浙江大学医学院附属第一医院[9]Department of Respiration, QinghaiPeople’s Hospital, Xining, China[10]Department of Respiration, The SecondHospital of Hebei Medical University, Shijiazhuang, China[11]Departmentof Pulmonary and Critical Care Medicine, Inner Mongolia People’s Hospital,Hohhot, China[12]Department of Pulmonary and Critical Care Medicine,People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China[13]Department of Pulmonary and Critical Care Medicine, The First AffiliatedHospital of Xi’an Jiaotong University, Xi’an, China[14]Department of Respiration,The First Affiliated Hospital of Harbin Medical University, Harbin, China[15]Department of Respiration, Henan Provincial People’s Hospital, Zhengzhou,China[16]Department of Respiration, Tianjin First Central Hospital, Tianjin,China[17]Department of Pulmonary and Critical Care Medicine, The SecondHospital of Jilin University, Changchun, China[18]Department of Respiration,Guizhou Provincial People’s Hospital, Guiyang, China[19]Department of Respiration,Tongji Hospital, Wuhan, China华中科技大学同济医学院附属同济医院[20]Department of Respiration, QingdaoMunicipal Hospital, Qingdao, Shandong, China[21]Department of Respiration,The First Affiliated Hospital of Anhui Medical University, Hefei, China[22]Departmentof Respiratory and Critical Care Medicine, West China School of Medicineand West China Hospital, Sichuan University, Chengdu, China[23]Departmentof Respiration, The First Affiliated Hospital of Nanchang University, Nanchang,China[24]Department of Respiration, Xiangya Hospital, Changsha, China[25]Department of Respiration, The First Affiliated Hospital of Guangxi MedicalUniversity, Nanning, China[26]Department of Respiration, The First AffiliatedHospital of Lanzhou University, Lanzhou, China[27]Department of Respiration,Kunming General Hospital of the People’s Liberation Army, Kunming, China[28]Department of Respiration, General Hospital of Ningxia Medical University,Yinchuan, China[29]Department of Respiration, Hainan General Hospital,Haikou, China[30]Department of Respiration, Shanxi Bethune Hospital, Taiyuan,China
Purpose While asthma comorbidities are associated with higher health care utilisation, lower quality of life and poorer asthma control, the impact of asthma comorbidities on hospitalisation for asthma exacerbation (H-AX) remains less recognised. We aim to analyse the impact of asthma comorbidities on H-AX. Methods Based on a national survey on asthma control and disease perception (CARN 2015 study), we analysed the impact of comorbidities on annual incidence and frequency of H-AX in China. Information on demographic characteristics, asthma comorbidities and annual incidence and frequency of H-AX were presented in this study. Results Among 3875 ambulatory asthma patients, 75.9% (2941/3875) had comorbidities, and 26.4% (1017/3858) experienced H-AX during past year. After adjusting for confounding factors such as demographic data, smoking status and asthma control, COPD [OR = 2.189, 95% CI (1.673, 2.863)] and coronary heart disease [OR = 1.387, 95% CI (1.032, 1.864)] were associated with higher annual incidence, while allergic rhinitis [OR = 0.692, 95% CI (0.588, 0.815)] was associated with lower annual incidence, of H-AX. In terms of frequency, allergic rhinitis [OR = 1.630, 95% CI (1.214, 2.187)], COPD [OR = 1.472, 95% CI (1.021, 2.122)] and anxiety [OR = 2.609, 95% CI (1.051, 6.477)] showed statistically significant correlation with frequent H-AX. Conclusions COPD and coronary heart disease were associated with higher annual incidence, while allergic rhinitis was associated with lower annual incidence of H-AX. Allergic rhinitis, COPD and anxiety were associated with frequent H-AX. Comorbidities may have an important role in the risk and frequency of annual hospitalisations due to asthma exacerbation. The goal of asthma control should rely on a multi-disciplinary treatment protocol.
基金：
latitudinal project of China-Japan Friendship Hospital [2018-HX-99]
第一作者单位：[1]Department of Pulmonary and Critical Care Medicine, China-Japan FriendshipHospital, Beijing 100029, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wenqiao Wang,Jiangtao Lin,Xin Zhou,et al.Associations between comorbidities and annual incidence plus frequency of asthma exacerbation hospitalisation during the past year: data from CARN study[J].BMC PULMONARY MEDICINE.2022,22(1):doi:10.1186/s12890-022-02038-3.
APA：
Wenqiao Wang,Jiangtao Lin,Xin Zhou,Changzheng Wang,Mao Huang...&Jianying Xu.(2022).Associations between comorbidities and annual incidence plus frequency of asthma exacerbation hospitalisation during the past year: data from CARN study.BMC PULMONARY MEDICINE,22,(1)
MLA：
Wenqiao Wang,et al."Associations between comorbidities and annual incidence plus frequency of asthma exacerbation hospitalisation during the past year: data from CARN study".BMC PULMONARY MEDICINE 22..1(2022)
