Objective: To explore the efficacy of antibiotic bone cement (ABC) combined with the modified tibial transverse transport (mTTT) on the treatment of severe diabetic foot with infection. Methods: A retrospective cohort study was conducted of 243 patients with TEXAS grade 3/4 stage D diabetic foot ulcers from December 2016 to December 2019. A total of 115 patients treated with mTTT were classified as the mTTT group (78 male and 37 female, mean age: 70.4 +/- 6 years) and 128 patients who were treated with ABC combined with mTTT were in the ABC + mTTT group (89 male and 39 female, mean age: 68.9 +/- 8 years). Follow-up records during treatment and 6 months after surgery were collected, including the time required for white blood cells (WBC) and C-reactive protein (CRP) to return to normal range, wound healing time, pain visual analog scale (VAS), ankle-brachial index (ABI), foot skin temperature, transcutaneous oxygen pressure measurement (TcPO2), complications, and other indicators. Normally distributed data were compared using the independent sample t-test, non-normally distributed data were analyzed by one-way ANOVA analysis of variance. Results: There were 128 cases in the ABC + mTTT group (89 male and 39 female, mean age: 68.9 +/- 8 years) treated with ABC and mTTT, and 115 cases in the TTT group (78 male and 37 female, mean age: 70.4 +/- 6 years) treated with mTTT alone. The time required for WBC and CRP to return to the normal range and wound healing time in the ABC + mTTT group were significantly shorter than those in the mTTT group (12.9 +/- 4.6 vs. 22.6 +/- 1.6 days, t = 3.979, p < 0.001; 25.3 +/- 1.3 vs. 31.3 +/- 2.3 days, t = 4.261, p = 0.001; 11.9 +/- 3.8 vs. 15.9 +/- 3.9 days, t = 4.539, p < 0.001). There were no significant intergroup differences in the foot skin temperature, VAS score, ABI, and TcPO2 (t = 0.349, 0.542, 0.765, 0.693 while all p > 0.05). Conclusion: Although the application of ABC with mTTT for treatment of diabetic foot ulcers did not affect the wound healing time and ankle blood supply in the mid-term, it could control ulcer infection faster and accelerate wound healing.
基金：
Capital's Funds for Health Improvement and Research [2020-2-4086]; Pilot project on clinical collaboration of major and difficult diseases of Chinese and Western medicine [201803190106]; National Key Research and Development Program of China [2019YFB1311403]; Key Laboratory of Trauma and Neural Regeneration (Peking University), Ministry of Education
第一作者单位：[1]Capital Med Univ, Beijing Chaoyang Hosp, Dept Orthopaed, Worker Stadium South Rd 8, Beijing 100020, Peoples R China[2]Beijing Longfu Hosp, Dept Orthopaed, Beijing, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Chaoyang Hosp, Dept Orthopaed, Worker Stadium South Rd 8, Beijing 100020, Peoples R China[4]Peking Univ, Peoples Hosp, Dept Trauma & Orthopaed, Beijing, Peoples R China[6]Peking Univ, Minist Educ, Key Lab Trauma & Neural Regenerat, Beijing, Peoples R China[7]Natl Ctr Trauma Med, Dept Orthopaed, Beijing, Peoples R China[*1]Department of Trauma and Orthopaedics, Diabetic Foot Treatment Centre, Peking University People’s Hospital, Peking University, National Center for Trauma Medicine, 11th Xizhimen South Street, Beijing, 100033, China[*2]Department of Orthopaedics, Beijing Chaoyang Hospital, Capital Medical University, The Worker Stadium South Road no.8, Chaoyang District, Beijing, 100020, China.
推荐引用方式(GB/T 7714)：
Ding Xiaofang,Yuan Yusong,Lu Hao,et al.Analysis of the Effect of Antibiotic Bone Cement in the Treatment of Diabetic Foot Ulcer through Tibia Transverse Transport[J].ORTHOPAEDIC SURGERY.2022,doi:10.1111/os.13412.
APA：
Ding, Xiaofang,Yuan, Yusong,Lu, Hao,Wang, Yuanli,Ji, Kunyu...&Zhou, Junlin.(2022).Analysis of the Effect of Antibiotic Bone Cement in the Treatment of Diabetic Foot Ulcer through Tibia Transverse Transport.ORTHOPAEDIC SURGERY,,
MLA：
Ding, Xiaofang,et al."Analysis of the Effect of Antibiotic Bone Cement in the Treatment of Diabetic Foot Ulcer through Tibia Transverse Transport".ORTHOPAEDIC SURGERY .(2022)
