单位：[1]Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China[2]Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China[3]Peking University China-Japan Friendship School of Clinical Medicine, Beijing, 100191, China
Background: Alzheimer's disease is a prevalent health problem with a heavy global burden. Definitely diagnosed by autopsy, the clear mechanism of Alzheimer's disease pathogenesis process needs to be illustrated. MicroRNAs are suggested to be involved in many diseases. We aimed to investigate the role of microRNA in Alzheimer's disease.Methods: We attempted to discover the role of microRNA in Alzheimer's disease by microarray bioinformatics analysis using autopsy sample data from the GEO database. Temporal cortex samples were included in this study. Bioinformatics analyses and visualization were processed based on R.Results: After filtering out significantly differential expressed microRNAs and genes, enrichment analyses of both microRNAs and genes were conducted, respectively. Then, we constructed a transcription fac-tor-microRNA-mRNA network and a protein-protein interaction network. In parallel, we used the receiver operating characteristic curve to evaluate the diagnostic value of microRNA. Based on the evidence, we finally identified hsa-miR-365b-5p as a key target in Alzheimer's disease.Conclusions: Hsa-miR-365b-5p act as a key target in Alzheimer's disease. It regulates Alzheimer's disease path-ogenesis process via neuroinflammation, Wnt and oxidative stress pathway which provides a potential target for Alzheimer's disease treatment.
基金：
National Natural Science Foundation of China; Central Health Research Project; [81974220]; [2020ZD10]
第一作者单位：[1]Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China[2]Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
通讯作者：
通讯机构：[1]Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China[2]Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China[3]Peking University China-Japan Friendship School of Clinical Medicine, Beijing, 100191, China[*1]Department of Neurology, China–Japan Friendship Hospital, No. 2 Yinghuayuan East Street, Chaoyang District, Beijing 100029, China.
推荐引用方式(GB/T 7714)：
Wang Yuye,Lv Shuang,Zhou Xiao,et al.Identification of hsa-miR-365b-5p's role in Alzheimer's disease: A combined analysis of miRNA and mRNA microarrays[J].NEUROSCIENCE LETTERS.2022,790:doi:10.1016/j.neulet.2022.136892.
APA：
Wang, Yuye,Lv, Shuang,Zhou, Xiao,Niu, Xiaoqian,Chen, Leian...&Peng, Dantao.(2022).Identification of hsa-miR-365b-5p's role in Alzheimer's disease: A combined analysis of miRNA and mRNA microarrays.NEUROSCIENCE LETTERS,790,
MLA：
Wang, Yuye,et al."Identification of hsa-miR-365b-5p's role in Alzheimer's disease: A combined analysis of miRNA and mRNA microarrays".NEUROSCIENCE LETTERS 790.(2022)
