单位：[1]Capital Med Univ, Affiliated Beijing Friendship Hosp, Dept Hematol, Beijing, Peoples R China临床科室血液科血液科首都医科大学附属北京友谊医院[2]Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, Dept Hematol, Beijing, Peoples R China[3]Northern Theater Gen Hosp, Dept Hematol, Shenyang, Peoples R China
Primary central nervous system lymphoma (PCNSL) is a highly aggressive brain tumor with poor prognosis if no treatment. The activation of the NF-kappa B (nuclear factor kappa-B) is the oncogenic hallmark of PCNSL, and it was driven by B cell receptor (BCR) and Toll-like receptor (TLR) signaling pathways. The emergence of Bruton's tyrosine kinase inhibitors (BTKis) has brought the dawn of life to patients with PCNSL. This review summarizes the management of PCNSL with BTKis and potential molecular mechanisms of BTKi in the treatment of PCNSL. And the review will focus on the clinical applications of BTKi in the treatment of PCNSL including the efficacy and adverse events, the clinical trials currently being carried out, the underlying mechanisms of resistance to BTKi and possible solutions to drug resistance.
第一作者单位：[1]Capital Med Univ, Affiliated Beijing Friendship Hosp, Dept Hematol, Beijing, Peoples R China
通讯作者：
通讯机构：[2]Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, Dept Hematol, Beijing, Peoples R China[3]Northern Theater Gen Hosp, Dept Hematol, Shenyang, Peoples R China
推荐引用方式(GB/T 7714)：
Shen Jing,Liu Jinghua.Bruton's tyrosine kinase inhibitors in the treatment of primary central nervous system lymphoma: A mini-review[J].FRONTIERS IN ONCOLOGY.2022,12:doi:10.3389/fonc.2022.1034668.
APA：
Shen, Jing&Liu, Jinghua.(2022).Bruton's tyrosine kinase inhibitors in the treatment of primary central nervous system lymphoma: A mini-review.FRONTIERS IN ONCOLOGY,12,
MLA：
Shen, Jing,et al."Bruton's tyrosine kinase inhibitors in the treatment of primary central nervous system lymphoma: A mini-review".FRONTIERS IN ONCOLOGY 12.(2022)
