单位：[1]Department of Orthodontics, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing 100050, China.[2]Biomaterials & Tissue Engineering Division, Department of Advanced Oral Sciences and Therapeutics, University Maryland School of Dentistry, Baltimore, MD 21201, USA.[3]Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.[4]Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.临床科室口腔科口腔科首都医科大学附属北京友谊医院[5]Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
Bone tissue engineering is a promising approach that uses seed-cell-scaffold drug delivery systems to reconstruct bone defects caused by trauma, tumors, or other diseases (e.g., periodontitis). Metformin, a widely used medication for type II diabetes, has the ability to enhance osteogenesis and angiogenesis by promoting cell migration and differentiation. Metformin promotes osteogenic differentiation, mineralization, and bone defect regeneration via activation of the AMP-activated kinase (AMPK) signaling pathway. Bone tissue engineering depends highly on vascular networks for adequate oxygen and nutrition supply. Metformin also enhances vascular differentiation via the AMPK/mechanistic target of the rapamycin kinase (mTOR)/NLR family pyrin domain containing the 3 (NLRP3) inflammasome signaling axis. This is the first review article on the effects of metformin on stem cells and bone tissue engineering. In this paper, we review the cutting-edge research on the effects of metformin on bone tissue engineering. This includes metformin delivery via tissue engineering scaffolds, metformin-induced enhancement of various types of stem cells, and metformin-induced promotion of osteogenesis, angiogenesis, and its regulatory pathways. In addition, the dental, craniofacial, and orthopedic applications of metformin in bone repair and regeneration are also discussed.
基金：
This work was supported by grants from the National Natural Science Foundation of China
[grant number (NSFC) 82071144 to Y.B.], the Innovation Research Team Project of Beijing Stomatological
Hospital, CapitalMedical University [grant number CXTD202203 to Y.B.], the Young Scientist Program
of Beijing Stomatological Hospital, CapitalMedical University [YSP202010 to Z.Z.], and the Capital’s
Funds for Health Improvement and Research [grant number CFH2020-2-2142 to K.Z.].
第一作者单位：[1]Department of Orthodontics, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing 100050, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Zhu Minjia,Zhao Zeqing,Xu Hockin H K,et al.Effects of Metformin Delivery via Biomaterials on Bone and Dental Tissue Engineering[J].International Journal Of Molecular Sciences.2022,23(24):doi:10.3390/ijms232415905.
APA：
Zhu Minjia,Zhao Zeqing,Xu Hockin H K,Dai Zixiang,Yu Kan...&Zhang Ke.(2022).Effects of Metformin Delivery via Biomaterials on Bone and Dental Tissue Engineering.International Journal Of Molecular Sciences,23,(24)
MLA：
Zhu Minjia,et al."Effects of Metformin Delivery via Biomaterials on Bone and Dental Tissue Engineering".International Journal Of Molecular Sciences 23..24(2022)
生物学