The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial
单位：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China 首都医科大学宣武医院[2]Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China 首都医科大学宣武医院[3]Key Laboratory of Neurodegenerative Diseases, Ministry of Education of the People’s Republic of China, Beijing, China [4]Collaborative Innovation Center for Language Ability, Jiangsu Normal University, Xuzhou, China [5]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing, China [6]Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing, China [7]IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China [8]Department of Geriatric, Fu Xing Hospital, Capital Medical University, Beijing, China [9]Department of Psychosomatic Medicine, University Medicine Rostock, Rostock, Germany [10]DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany [11]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China 首都医科大学宣武医院[12]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China [13]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China [14]National Clinical Research Center for Geriatric Disorders, Beijing, China [15]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China临床科室神经内科神经内科首都医科大学附属北京友谊医院
Introduction: Evidence for the efficacy of cognitive training in patients with subcortical vascular cognitive impairment no dementia is still lacking. Methods: A randomized, active controlled design using multidomain, adaptive, computerized cognitive training for 30 minutes, 5 days/week for 7 weeks. Assessments included global cognitive function and executive function (primary outcomes) and brain functional connectivity and structural changes (secondary outcomes). Results: Sixty patients were randomized across three medical centers in Beijing. At the end of the intervention, the cognitive training group showed significant improvement in Montreal Cognitive Assessment relative to the active control group (P = .013) and significantly increased functional connectivity between the left dorsolateral prefrontal cortex and medial prefrontal cortex, which was significantly correlated with Montreal Cognitive Assessment change (P = .017). Discussion: Computerized cognitive training significantly improved global cognitive function, which was supported by the improved brain plasticity. Incorporation of biomarkers should be implemented in cognitive training trials. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
基金：
National Key R&D Program of China [2017YFC1310102]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81671040, 31571156, 31871133, 81701044]; Beijing Municipal Administration of Hospital's Youth Program [QML20170801]; Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [Z151100004015078]
第一作者单位：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China [3]Key Laboratory of Neurodegenerative Diseases, Ministry of Education of the People’s Republic of China, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China [3]Key Laboratory of Neurodegenerative Diseases, Ministry of Education of the People’s Republic of China, Beijing, China
推荐引用方式(GB/T 7714)：
Tang Yi,Xing Yi,Zhu Zude,et al.The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial[J].ALZHEIMERS & DEMENTIA.2019,15(5):605-614.doi:10.1016/j.jalz.2019.01.009.
APA：
Tang, Yi,Xing, Yi,Zhu, Zude,He, Yong,Li, Fang...&Jia, Jianping.(2019).The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial.ALZHEIMERS & DEMENTIA,15,(5)
MLA：
Tang, Yi,et al."The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial".ALZHEIMERS & DEMENTIA 15..5(2019):605-614
医学