单位：[1]Renal Division, Department of Medicine, Peking University First Hospital.Peking University Institute of Nephrology.Key Laboratory of Renal Disease,Ministry of Health of China.Key Laboratory of Chronic Kidney DiseasePrevention and Treatment (Peking University), Ministry of Education, Beijing,China[2]Department of Nephrology, China-Japan Friendship Hospital, Beijing,China[3]Department of Nephrology, Ruijin Hospital, Shanghai Jiao TongUniversity, School of Medicine, Shanghai, China[4]Renal Division, XinhuaHospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China[5]Department of Nephrology, the First Affiliated Hospital, Sun Yat-senUniversity, Guangzhou, China院本部南沙医院内科肾内科内科肾内科中山大学附属第一医院[6]Department of Nephrology, Beijing FriendshipHospital, Capital Medical University, Beijing, China[7]Kidney Diseases Center,First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou,China浙江大学医学院附属第一医院[8]Department of Nephrology, Beijing Chaoyang Hospital, CapitalMedical University, Beijing, China北京朝阳医院[9]Department of Nephrology, Shanghai FirstPeople s Hospital, Shanghai Jiaotong University, Shanghai, China[10]Department of Nephrology, Beijing Hospital, Beijing, China[11]Departmentof Nephrology, Xijing Hospital, Fourth Military Medical University, Xi’an,China[12]Department of Nephrology, Peking University Third Hospital, Beijing,China[13]Department of Nephrology, Shuguang Hospital, Shanghai Universityof Traditional Chinese Medicine, Shanghai, China[14]Department ofNephrology, Huashan Hospital, Fudan University, Shanghai, China[15]Department of Nephrology, The General Hospital of the People's LiberationArmy, Beijing, China[16]Renal Division, Hospital Peking of Shenzhen,Shenzhen, China[17]Department of Nephrology, The 455th Hospital of PLA,Shanghai, China[18]Department of Nephrology, Xuanwu Hospital, CapitalMedical University, Beijing, China首都医科大学宣武医院[19]Department of Nephrology, GuangdongGeneral Hospital, Guangzhou, China[20]Renal Division, Jiangsu ProvincialHospital, Nanjing, China[21]Department of internal medicine, Shantou CentralHospital, Shantou, China[22]Department of Nephrology, Nanfang Hospital,The Southern Medical University, Guangzhou, China[23]Department ofNephrology, Fujian Provincial Hospital, Fuzhou, China[24]Department ofNephrology, Changzheng Hospital, Second Military Medical University,Shanghai, China[25]Department of Nephrology, Sichuan Provincial People’ sHospital, Chengdu, China[26]Department of Nephrology, Qianfoshan Hospital,Shandong University, Jinan, China[27]Renal Division, Renji Hospital, ShanghaiJiao Tong University School of Medicine, Shanghai, China[28]Department ofNephrology, Peking University People’s Hospital, Beijing, China[29]Institute ofNephrology and Division of Nephrology, and Key Laboratory of Ministry ofHealth, Peking University First Hospital, 8 Xishiku Street, Xicheng District,Beijing 100034, China
Background: Mineral and bone disorder (MBD) in patients with chronic kidney disease is associated with increased morbidity and mortality. Studies regarding the status of MBD treatment in developing countries, especially in Chinese dialysis patients are extremely limited. Methods: A cross-sectional study of 1711 haemodialysis (HD) patients and 363 peritoneal dialysis (PD) patients were enrolled. Parameters related to MBD, including serum phosphorus (P), calcium (Ca), intact parathyroid hormone (iPTH) were analyzed. The achievement of MBD targets was compared with the results from the Dialysis Outcomes and Practice Study (DOPPS) 3 and DOPPS 4. Factors associated with hyperphosphatemia were examined. Results: Total 2074 dialysis patients from 28 hospitals were involved in this study. Only 38.5%, 39.6% and 26.6% of them met the Kidney Disease Outcomes Quality Initiative (K/DOQI) defined targets for serum P, Ca and iPTH levels. Serum P and Ca levels were statistically higher (P < 0.05) in the HD patients compared with those of PD patients, which was (6.3 +/- 2.1) mg/dL vs (5.7 +/- 2.0) mg/dL and (9.3 +/- 1.1) mg/dL vs (9.2 +/- 1.1) mg/dL, respectively. Serum iPTH level were statistically higher in the PD patients compared with those of HD patients (P = 0.03). The percentage of patients reached the K/DOQI targets for P (37.6% vs 49.8% vs 54.5%, P < 0.01), Ca (38.6% vs 50.4% vs 56.0%, P < 0.01) and iPTH (26.5% vs 31.4% vs 32.1%, P < 0.01) were lower among HD patients, compared with the data from DOPPS 3 and DOPPS 4. The percentage of patients with serum phosphorus level above 5.5 mg/dL was 57.4% in HD patients and 47.4% in PD patients. Age, dialysis patterns and region of residency were independently associated with hyperphosphatemia. Conclusions: Status of MBD is sub-optimal among Chinese patients receiving dialysis. The issue of hyperphosphatemia is prominent and needs further attention.
第一作者单位：[1]Renal Division, Department of Medicine, Peking University First Hospital.Peking University Institute of Nephrology.Key Laboratory of Renal Disease,Ministry of Health of China.Key Laboratory of Chronic Kidney DiseasePrevention and Treatment (Peking University), Ministry of Education, Beijing,China[26]Department of Nephrology, Qianfoshan Hospital,Shandong University, Jinan, China
共同第一作者：
通讯作者：
通讯机构：[1]Renal Division, Department of Medicine, Peking University First Hospital.Peking University Institute of Nephrology.Key Laboratory of Renal Disease,Ministry of Health of China.Key Laboratory of Chronic Kidney DiseasePrevention and Treatment (Peking University), Ministry of Education, Beijing,China[28]Department ofNephrology, Peking University People’s Hospital, Beijing, China[29]Institute ofNephrology and Division of Nephrology, and Key Laboratory of Ministry ofHealth, Peking University First Hospital, 8 Xishiku Street, Xicheng District,Beijing 100034, China
推荐引用方式(GB/T 7714)：
Xianglei Kong,Luxia Zhang,Ling Zhang,et al.Mineral and bone disorder in Chinese dialysis patients: a multicenter study[J].BMC NEPHROLOGY.2012,13:doi:10.1186/1471-2369-13-116.
APA：
Xianglei Kong,Luxia Zhang,Ling Zhang,Nan Chen,Yong Gu...&Haiyan Wang.(2012).Mineral and bone disorder in Chinese dialysis patients: a multicenter study.BMC NEPHROLOGY,13,
MLA：
Xianglei Kong,et al."Mineral and bone disorder in Chinese dialysis patients: a multicenter study".BMC NEPHROLOGY 13.(2012)
