单位：[1]Department of Otorhinolaryngology, Head and Neck Surgery, Peking University First Hospital, 8# Xishiku Street, Western District, Beijing 100034, China [2] Department of Otorhinolaryngology, Head and Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital, 6# Fucheng Road, Haidian District, Beijing 100048, China [3] Department of Otorhinolaryngology, Head and Neck Surgery, Changhai Hospital, Second Military Medical University, 168# Changhai Street, Yangpu District, Shanghai 200433, China [4] Department of Otorhinolaryngology, Head and Neck Surgery, Peking University Third Hospital, Beijing, China [5]Department of Otorhinolaryngology, Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China [6]Department of Otorhinolaryngology, Head and Neck Surgery, Peking University People’s Hospital, Beijing, China [7] Department of Otorhinolaryngology, Head and Neck Surgery, China-Japan Friendship Hospital, Beijing, China [8]Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China [9] Department of Otorhinolaryngology, Head and Neck Surgery, Afliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China [10] Department of Otorhinolaryngology, Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China [11] Department of Otorhinolaryngology, Head and Neck Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China 华中科技大学同济医学院附属协和医院[12] Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China 四川大学华西医院[13] Department of Otorhinolaryngology, Head and Neck Surgery, The First Afliated Hospital of China Medical University, Shenyang, Liaoning, China [14] Department of Otorhinolaryngology Head and Neck Surgery, The First Afliated Hospital of Nanchang University, Nanchang, Jiangxi, China [15] Department of Otorhinolaryngology, Head and Neck Surgery, Tianjin First Central Hospital, Tianjin, China [16] Department of Otorhinolaryngology, Head and Neck Surgery, The First Afliated Hospital of Xiamen University, Xiamen, Fujian, China [17] Department of Otorhinolaryngology Head and Neck Surgery, Henan Provincial People’s Hospital, Zhengzhou, Henan, China [18] Department of Otorhinolaryngology, Head and Neck Surgery, Afliated Sixth People’s Hospital of Shanghai Jiaotong University, Shanghai, China [19]Department of Otorhinolaryngology, Head and Neck Surgery, The Third Afliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China [20]Department of Otorhinolaryngology, Head and Neck Surgery, Hainan Provincial People’s Hospital, Hiakou, Hainan, China [21]Department of Otorhinolaryngology, Head and Neck Surgery, The Second Afliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China [22]Department of Otorhinolaryngology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China 北京大学深圳医院深圳市康宁医院深圳医学信息中心[23] Department of Otorhinolaryngology, Head and Neck Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, China [24]Department of Otorhinolaryngology, Head and Neck Surgery, Clinical Medical School, Yangzhou University, Yangzhou, Jiangsu, China [25]Department of Otorhinolaryngology, Head and Neck Surgery, Afliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China [26]Department of Otorhinolaryngology, Head and Neck Surgery, The Second Afliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China [27]Department of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China[28]Department of Otorhinolaryngology Head and Neck Surgery, Guangdong Provincial People’s Hospital, Guangzhou, Guangdong, China [29]Department of Otorhinolaryngology Head and Neck Surgery, Afliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China [30]Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China 临床科室耳鼻咽喉头颈外科耳鼻咽喉头颈外科首都医科大学附属北京友谊医院[31] Department of Otolaryngology, Head and Neck Surgery, The First Afliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, China [32]Department of Otorhinolaryngology, Head and Neck Surgery, The First Afliated Hospital of Fujian Medical University, Fuzhou, Fujian, China [33]Department of Otorhinolaryngology, Head and Neck Surgery, Chengdu First People’s Hospital, Chengdu, Sichuan, China [34]Department of Otorhinolaryngology, Head and Neck Surgery, Xinqiao Hospital, Army Military Medical University, Chongqing, China [35]Department of Otorhinolaryngology, Head and Neck Surgery, Wuxi People’s Hospital, Wuxi, Jiangsu, China [36]Department of Otorhinolaryngology, Head and Neck Surgery, Dalian Central Hospital, Dalian, Liaoning, China 大连市中心医院[37]Department of Otorhinolaryngology, Head and Neck Surgery, Shenzhen University General Hospital, Shenzhen, Guangdong, China 深圳大学总医院深圳市康宁医院深圳医学信息中心[38]Department of Otorhinolaryngology, Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang, Hebei, China [39]Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an, Shaanxi, China [40]Department of Otorhinolaryngology Head and Neck Surgery, Jiangmen Central Hospital, Jiangmen, Guangdong, China [41]Department of Otorhinolaryngology, Head and Neck Surgery, Afliated Hospital of Southwest Medical University, Luzhou, Sichuan, China [42]Department of Voice, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China [43]Department of Otorhinolaryngology, Head and Neck Surgery, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China [44]Department of Otorhinolaryngology, Head and Neck Surgery, The Second Afliated Hospital of Anhui Medical University, Hefei, Anhui, China [45]Department of Otorhinolaryngology, Head and Neck Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China [46]Department of Otorhinolaryngology, Head and Neck Surgery, The First Afliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China [47]Department of Otorhinolaryngology, Head and Neck Surgery, PLA Strategic Support Force Characteristic Medical Center, Beijing, China [48]Department of Otorhinolaryngology Head and Neck Surgery, Sichuan Provincial Corps Hospital, Chinese People’s Armed Police Force, Leshan, Sichuan, China [49]Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of Northern Theater Command, Shenyang, Liaoning, China [50]Department of Otorhinolaryngology Head and Neck Surgery, The First Hospital of Longyan City, Longyan, Fujian, China [51]Department of Otorhinolaryngology Head and Neck Surgery, Chongqing General Hospital, Chongqing, China [52]Department of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China [53]Department of Otorhinolaryngology, Head and Neck Surgery, The First Afliated Hospital of Hainan Medical College, Haikou, Hainan, China [54]Department of Otorhinolaryngology, Head and Neck Surgery, The People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China [55]Department of Otorhinolaryngology Head and Neck Surgery, Changsha Central Hospital, Changsha, Hunan, China [56]Department of Otorhinolaryngology Head and Neck Surgery, The Fifth Afliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China [57]Department of Otorhinolaryngology Head and Neck Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China [58]Department of Otorhinolaryngology Head and Neck Surgery, Zhengzhou Central Hospital, Zhengzhou, Henan, China [59]Department of Otorhinolaryngology Head and Neck Surgery, The First People’s Hospital of Shangqiu City, Shangqiu, Henan, China [60]Department of Otorhinolaryngology, Head and Neck Surgery, Linfen People’s Hospital, Linfen, Shanxi, China [61]Department of Otorhinolaryngology, Head and Neck Surgery, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China [62]Department of Otorhinolaryngology Head and Neck Surgery, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China [63]Department of Otorhinolaryngology Head and Neck Surgery, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, China [64] Department of Otorhinolaryngology Head and Neck Surgery, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China [65] Department of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China [66]Department of Otorhinolaryngology, Head and Neck Surgery, The Afliated Hospital of Qinghai University, Xining, Qinghai, China[67]Department of Otorhinolaryngology, Head and Neck Surgery, Chizhou People’s Hospital, Chizhou, Anhui, China [68]Department of Otorhinolaryngology, Head and Neck Surgery, Wuhan Third Hospital, Wuhan, Hubei, China [69]Department of Otorhinolaryngology, Head and Neck Surgery, Gansu Provincial Hospital, Lanzhou, Gansu, China [70]Department of Otorhinolaryngology Head and Neck Surgery, Xinjiang Military Command General Hospital, Urumqi, Xinjiang, China [71]Department of Otorhinolaryngology, Head and Neck Surgery, Afliated Hospital of Chifeng College, Chifeng, Inner Mongolia, China [72]Department of Otorhinolaryngology Head and Neck Surgery, The People’s Hospital of Dazu District, Chongqing, China [73]Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Union Medical Center, Tianjin, China [74]Department of Otorhinolaryngology Head and Neck Surgery, Qinghai Red Cross Hospital, Xining, Qinghai, China [75]Department of Otorhinolaryngology, Head and Neck Surgery, Fenyang Hospital, Shanxi Province, Fenyang, Shanxi, China
Purpose Using the Reflux Symptom Index (RSI), this nationwide study aimed to investigate the incidence, diagnostic status, risk factors, and common symptoms of adult laryngopharyngeal reflux disease (LPRD) at otorhinolaryngology-head and neck surgery (OHNS) clinics in China. Methods This multicenter cross-sectional survey began at the different institutions ranged from July to October 2017, and the duration was 12 months. A total of 90,440 eligible patients were finally enrolled from 72 medical institutions in China. All these patients completed the questionnaire based on RSI. In this study, LPRD was defined as RSI > 13. Results There were 9182 with LPRD among the 90,440 eligible participants (10.15%). However, only 1294 had a history of LPRD diagnosis among those with LPRD (14.09%). There were regional differences in the frequency of LPRD (P < 0.001). The proportions of patients with LPRD in males (vs. females), middle- and old-aged patients (vs. young), with current smoking history (vs. no smoking), and current drinking history (vs. no drinking) were significantly higher (all P < 0.001). Middle and old age, current smoking, and drinking history were independent predictors of LPRD (all P < 0.001, OR 1.240, 1.261, and 1.481, respectively). "Sensations of something stuck in throat or a lump in throat", "clearing throat", and "excess throat mucus or postnasal drip" were the most frequent clinical symptoms in patients with LPRD. Conclusions LPRD has a high incidence at the OHNS clinics in China. However, the diagnostic status of this disease is not optimistic. Older age, smoking, and drinking history were risk factors for LPRD.
第一作者单位：[1]Department of Otorhinolaryngology, Head and Neck Surgery, Peking University First Hospital, 8# Xishiku Street, Western District, Beijing 100034, China
通讯作者：
推荐引用方式(GB/T 7714)：
Shuifang Xiao,Jinrang Li,Hongliang Zheng,et al.An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China[J].EUROPEAN ARCHIVES of OTO-RHINO-LARYNGOLOGY.2020,277(10):2829-2838.doi:10.1007/s00405-020-06045-0.
APA：
Shuifang Xiao,Jinrang Li,Hongliang Zheng,Yan Yan,Xiangping Li...&Jinlong Ren.(2020).An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China.EUROPEAN ARCHIVES of OTO-RHINO-LARYNGOLOGY,277,(10)
MLA：
Shuifang Xiao,et al."An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China".EUROPEAN ARCHIVES of OTO-RHINO-LARYNGOLOGY 277..10(2020):2829-2838
