The motility of esophageal sphincters during liquid and solid bolus swallows: a multicenter normative value study of high-resolution manometry in China
单位：[1]Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China华中科技大学同济医学院附属协和医院[2]Division of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[3]Division of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China[4]Division of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China[5]Division of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China江苏省人民医院[6]Division of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China[7]Division of Gastroenterology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China[8]Division of Gastroenterology, The First Hospital of Jilin University, Changchun, Jilin, China[9]Division of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China临床科室国家中心消化分中心消化内科首都医科大学附属北京友谊医院[10]Division of Gastroenterology, Peking University Third Hospital, Beijing, China[11]State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Disease, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China
BackgroundIt is gradually accepted that solid bolus swallow needs to be added to the procedure of manometry. The motility differences in the upper esophageal sphincter (UES) and lower esophageal sphincter (LES) were not well described. Sierra Scientific Instruments solid-state high-resolution manometry (HRM) system, the most popular HRM system in China, lacks the Chinese normative values for both liquid and solid bolus swallow parameters. MethodsThe esophageal HRM data of 88 healthy volunteers were analyzed. The parameters of both sphincters in resting stage were summarized and those during solid and liquid swallows were compared. Key ResultsNormative HRM values of sphincter parameters in solid and liquid bolus swallows in China were established. The UES residual pressure of solid bolus swallows was lower than that of liquid bolus (0.35.5mm Hg vs 4.8 +/- 5.9mm Hg, P=.000). The time parameters of UES relaxation between two types of bolus swallows were similar. In solid bolus swallows, the intrabolus pressure (IBP) (13.8 +/- 5.1mm Hg vs 10.9 +/- 5.7mm Hg, P=.000) and LES relaxation time (11.0 +/- 2.1seconds vs 8.7 +/- 1.3seconds, P=.000) were higher. The 4-second integrated relaxation pressure between both bolus swallows was similar. Conclusions & InferencesThe function of the UES and LES between solid and liquid bolus swallows is different. Chinese HRM parameters are different from the Chicago Classification (, Number ChiCTR-EOC-15007147).
基金：
Foundation of the Key Clinical Project of the Ministry of Health of China, China [2010439]
第一作者单位：[1]Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
通讯作者：
通讯机构：[1]Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China[*1]Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
推荐引用方式(GB/T 7714)：
X.-L. Xiang,A. Wang,L. Tu,et al.The motility of esophageal sphincters during liquid and solid bolus swallows: a multicenter normative value study of high-resolution manometry in China[J].NEUROGASTROENTEROLOGY and MOTILITY.2017,29(1):doi:10.1111/nmo.12914.
APA：
X.-L. Xiang,A. Wang,L. Tu,M.-Y. Ke,Y.-S. Yang...&Xiao-Hua Hou.(2017).The motility of esophageal sphincters during liquid and solid bolus swallows: a multicenter normative value study of high-resolution manometry in China.NEUROGASTROENTEROLOGY and MOTILITY,29,(1)
MLA：
X.-L. Xiang,et al."The motility of esophageal sphincters during liquid and solid bolus swallows: a multicenter normative value study of high-resolution manometry in China".NEUROGASTROENTEROLOGY and MOTILITY 29..1(2017)
