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Analysis of the Gut Microflora in Patients With Parkinson's Disease

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收录情况： ◇ SCIE

作者：

单位： [1]Neurology Department of China - Japan Friendship Hospital, Beijing, China, [2]Institute of Microbiology, Chinese Academy ofSciences, Beijing, China, [3]Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China, [4]CollaborativeInnovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine,Zhejiang University, Hangzhou, China

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关键词： Parkinson's disease gut microflora Illumina MiSeq 16S rRNA gene Prevotella Turicibacter

摘要：

This study was conducted to explore the composition of the fecal microflora of Chinese Parkinson's disease (PD) patients, as well as to explore links between PD clinical features and antiparkinsonian medications on the gut microflora. Seventy-two PD cases [59 patients suffering from PD for >1 year (OPD) and 13 new PD (NPD) patients] were studied. Microflora communities in the feces of the patients and corresponding healthy controls (HCs) were examined using high-throughput Illumina MiSeq sequencing targeting the 16S rRNA gene. The gut microflora of OPD patients contained high levels of Rikenellaceae compared to corresponding HCs. In addition, significantly higher levels of Turicibacteraceae were found in the NPD group compared to the corresponding HCs. The genera Turicibacter and Prevotella were significantly correlated with the PD severity scores. Our findings that some fecal microflora were closely related to PD clinical characteristics may enhance our understanding of the pathogenesis and treatment of PD.

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出版当年[2018]版：

大类 | 2 区医学

小类 | 3 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区神经科学

JCR分区：

出版当年[2017]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q2 NEUROSCIENCES

影响因子： 最新[2023版] 3.2 最新五年平均[2021-2025] 4.3 出版当年[2017版] 3.877 出版当年五年平均[2013-2017] 4.294 出版前一年[2016版] 3.566 出版后一年[2018版] 3.648

第一作者：

第一作者单位： [1]Neurology Department of China - Japan Friendship Hospital, Beijing, China,

通讯作者：

通讯机构： [2]Institute of Microbiology, Chinese Academy ofSciences, Beijing, China, [3]Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China, [4]CollaborativeInnovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine,Zhejiang University, Hangzhou, China

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