单位：[1]Department of Obstetrics and Gynaecology, China-Japan Friendship Hospital, Beijing, China[2]Pathology Institute, University of Freiburg, Baden-Wuerttemberg, Germany[3]Department of Obstetrics and Gynecology, University of Freiburg, Baden- Wuerttemberg, Germany
Ovarian cancer (OC) has a high mortality rate among women worldwide. However, even with the advances in detection and therapeutics, the number of cases is increasing worldwide. Increasingly, microRNAs (miRNAs), including miR-497-5p, have been implicated in the progression of many cancers, but the role of miR-497-5p in OC remains unknown. The purpose of this study was to investigate the underlying molecular mechanism of miR-497-5p in OC. Herein, we find that miR-497-5p is down-regulated in OC tissues, and overexpression of miR-497-5p enhances apoptosis in OC cells. The increased apoptosis was correlated with enhanced expression of apoptosis-related proteins. MiR-497-5p directly bound the 3'-untranslated region of metadherin (MTDH), leading to the reduction of MTDH in mRNA and protein levels. Moreover, MTDH knockout promoted the apoptosis of OC cells. Taken together, we conclude that miR-497-5p contributes to cell apoptosis in OC by regulating MTDH.
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区移植4 区细胞与组织工程
最新[2025]版：
大类|4 区医学
小类|3 区移植4 区细胞与组织工程4 区医学：研究与实验
JCR分区：
出版当年[2018]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2TRANSPLANTATIONQ3CELL & TISSUE ENGINEERING
最新[2023]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2TRANSPLANTATIONQ3CELL & TISSUE ENGINEERING
第一作者单位：[1]Department of Obstetrics and Gynaecology, China-Japan Friendship Hospital, Beijing, China
通讯作者：
通讯机构：[1]Department of Obstetrics and Gynaecology, China-Japan Friendship Hospital, Beijing, China[*1]Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, Chaoyang District, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Liu Chunyan,Bordeaux Anne,Hettich Stanka,et al.MicroRNA-497-5p Functions as a Modulator of Apoptosis by Regulating Metadherin in Ovarian Cancer[J].CELL TRANSPLANTATION.2020,29:doi:10.1177/0963689719897061.
APA：
Liu, Chunyan,Bordeaux, Anne,Hettich, Stanka&Han, Suhui.(2020).MicroRNA-497-5p Functions as a Modulator of Apoptosis by Regulating Metadherin in Ovarian Cancer.CELL TRANSPLANTATION,29,
MLA：
Liu, Chunyan,et al."MicroRNA-497-5p Functions as a Modulator of Apoptosis by Regulating Metadherin in Ovarian Cancer".CELL TRANSPLANTATION 29.(2020)
