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Genistein inhibited the proliferation of kidney cancer cells via CDKN2a hypomethylation: role of abnormal apoptosis

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收录情况： ◇ SCIE

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单位： [1]Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China [2]Yanjing Medical College, Capital Medical University, Beijing 100069, China

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关键词： Genistein Kidney cancer cells CDKN2a hypomethylation Proliferation Apoptosis

摘要：

Introduction Genistein is recognized as a potent anti-oxidant in soybean-enriched foods, which is a kind of phytoestrogen involved in anticancer activity in various cancers. Objective The objective of this study was to investigate the molecular mechanism of CDKN2a hypomethylation involved in the anti-tumor effect of genistein on kidney cancer. Methods The CDKN2a expression was measured using qRT-PCR. The level of CDKN2a methylation was detected using methylation-specific PCR. The apoptosis was detected via flow-cytometric analysis. The cell viability was detected using the 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results Our results indicated that genistein induced cell apoptosis and inhibited the cell proliferation of kidney cancer cells. Moreover, genistein increased the expression of CDKN2a and decreased CDKN2a methylation. Conclusions Our results demonstrated that the anti-tumor effect of genistein might induce cell apoptosis and inhibit the proliferation of kidney cancer cells via regulating CDKN2a methylation.

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出版当年[2019]版：

大类 | 4 区医学

小类 | 4 区泌尿学与肾脏学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区泌尿学与肾脏学

JCR分区：

出版当年[2018]版：

Q3 UROLOGY & NEPHROLOGY

最新[2023]版：

Q3 UROLOGY & NEPHROLOGY

影响因子： 最新[2023版] 1.8 最新五年平均[2021-2025] 2 出版当年[2018版] 1.596 出版当年五年平均[2014-2018] 1.56 出版前一年[2017版] 1.692 出版后一年[2019版] 1.843

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第一作者单位： [1]Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

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