单位：[1]Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China[2]Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China[3]Human Genetics Resource Preservation Center of Wuhan University, Wuhan, China[4]Human Genetics Resource Preservation Center of Hubei Province, Wuhan, China[5]Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center, Wuhan, China[6]Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China临床科室泌尿外科泌尿外科首都医科大学附属北京友谊医院
Peroxisome proliferator-activated receptor gamma (PPAR gamma), a member of the nuclear receptor superfamily, participates in multiple physiological and pathological processes. Extensive studies have revealed the relationship between PPAR gamma and various tumors. However, the expression and function of PPAR gamma in bladder cancer seem to be controversial. It has been demonstrated that PPAR gamma affects the occurrence and progression of bladder cancer by regulating proliferation, apoptosis, metastasis, and reactive oxygen species (ROS) and lipid metabolism, probably through PPAR gamma-SIRTI feedback loops, the PI3K-Akt signaling pathway, and the WNT/beta-catenin signaling pathway. Considering the frequent relapses after chemotherapy, some researchers have focused on the relationship between PPAR gamma and chemotherapy sensitivity in bladder cancer. Moreover, the feasibility of PPAR gamma ligands as potential therapeutic targets for bladder cancer has been uncovered. Taken together, this review summarizes the relevant literature and our findings to explore the complicated role and function of PPAR gamma in bladder cancer.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81902603]; Health commission of Hubei Province scientific research project [WJ2019H013]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2042018kf1040, 2042019kf0176]
第一作者单位：[1]Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China[5]Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center, Wuhan, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China[2]Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China[3]Human Genetics Resource Preservation Center of Wuhan University, Wuhan, China[4]Human Genetics Resource Preservation Center of Hubei Province, Wuhan, China[5]Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center, Wuhan, China
推荐引用方式(GB/T 7714)：
Peng Tianchen,Wang Gang,Cheng Songtao,et al.The role and function of PPAR gamma in bladder cancer[J].JOURNAL of CANCER.2020,11(13):3965-3975.doi:10.7150/jca.42663.
APA：
Peng, Tianchen,Wang, Gang,Cheng, Songtao,Xiong, Yaoyi,Cao, Rui...&Xiao, Yu.(2020).The role and function of PPAR gamma in bladder cancer.JOURNAL of CANCER,11,(13)
MLA：
Peng, Tianchen,et al."The role and function of PPAR gamma in bladder cancer".JOURNAL of CANCER 11..13(2020):3965-3975
