单位：[1]Neurology Department of China, Japan Friendship Hospital, Beijing, People’s Republic of China[2]Thoracic Surgery Department of China, Japan Friendship Hospital, Beijing, People’s Republic of China
This study aimed to confirm the use of microRNA (miR)-30c-5p and miR-373 as the potential biomarkers for Parkinson's disease (PD). In this study, 148 patients with PD admitted to our hospital were enrolled as the research group (RG) and 126 physically examined healthy individuals as the control group (CG) between December 2017 and June 2018. Serum miR-30c-5p and miR-373 expressions in both groups were determined by quantitative real-time polymerase chain reaction. Furthermore, the correlation of their expressions with PD severity was determined by Spearman's correlation analysis. Serum miR-30c-5p and miR-373 expressions were higher in RG than in CG (both P < 0.001). Their expressions were not related to smoking history and diabetes mellitus history in RG (both P > 0.001) but were related to sex, age, coronary heart disease history, depression history, and Hoehn-Yahr score (all P < 0.05). Moreover, the relative expressions of serum miR-30c-5p and miR-373 were positively correlated with PD severity (P < 0.05). MiR-30c-5p and miR-373 may be involved in PD development and progression and can be adopted as potential biomarkers for PD.
第一作者单位：[1]Neurology Department of China, Japan Friendship Hospital, Beijing, People’s Republic of China
通讯作者：
通讯机构：[1]Neurology Department of China, Japan Friendship Hospital, Beijing, People’s Republic of China[*1]Neurology Department of China, Japan Friendship Hospital, No. 2 Yinghua East Street, Chaoyang District, Beijing 100029, People’s Republic of China
推荐引用方式(GB/T 7714)：
Zhang Lin-wei,Zhang Jin,Wang Kang,et al.Serum microRNA-30c-5p and microRNA-373 expressions as potential biomarkers for Parkinson's disease[J].ALL LIFE.2020,13(1):194-200.doi:10.1080/26895293.2020.1741453.
APA：
Zhang, Lin-wei,Zhang, Jin,Wang, Kang&Wang, Ren-bin.(2020).Serum microRNA-30c-5p and microRNA-373 expressions as potential biomarkers for Parkinson's disease.ALL LIFE,13,(1)
MLA：
Zhang, Lin-wei,et al."Serum microRNA-30c-5p and microRNA-373 expressions as potential biomarkers for Parkinson's disease".ALL LIFE 13..1(2020):194-200
