单位：[1]Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, P.R. China[2]Department of Oral Pathology, Beijing Stomatological Hospital, Capital Medical University, Beijing, P.R. China[3]Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing, P.R. China临床科室口腔科口腔科首都医科大学附属北京友谊医院
Objective The purpose of this study was to explore the necessity of adjuvant radiotherapy for well-differentiated pT3-4aN0M0 OSCC without other negative features histologically. Patients and Methods This is a double-center, ambispective cohort study enrolling 250 patients with well-differentiated pT3-4aN0M0 OSCC. Results A total of 250 patients were enrolled in the double-center study, 155(62.0%) men and 95 (38.0%) women, and the mean age was 60.1 +/- 11.1 years. T staging was classified as follows: T3 (n = 99, 39.6%) and T4a (n = 151, 60.4%). Kaplan-Meier analysis showed that there was no significant difference in the DSS between patients who received adjuvant radiotherapy (72.2%) and those who did not (77.4%) (p = .615). Specifically, no significant difference was found in the DSS of pT3N0M0 or pT4aN0M0 patients who received adjuvant radiotherapy compared with those who did not (pT3N0M0: 71.9% vs. 75.8%, p = .993; pT4aN0M0: 72.4% vs. 78.5%, p = .491). The Cox proportional hazards regression models showed that no factor was independent prognostic factor for pT3-4aN0M0 patients, or pT3N0M0 subgroup or pT4aN0M0 subgroup in DSS. And no independent prognostic factor was found for the surgery-alone subgroup and adjuvant radiotherapy subgroup. Conclusions The results showed that adjuvant radiotherapy did not obviously improve the prognosis of pT3-4aN0M0 well-differentiated OSCC without other negative features.
基金：
Beijing Municipal Administration of Hospitals Clinical medicine Development of special funding support [XMLX201819]; Shanghai Science and Technology CommitteeShanghai Science & Technology Committee [18DZ2291500]
第一作者单位：[1]Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, P.R. China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, P.R. China[*1]Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, No. 4 Tian Tan Xi Li, Dongcheng District, Beijing 100050, P.R. China.
推荐引用方式(GB/T 7714)：
Li Bo,Wang Chong,Yuan Xiaohong,et al.Is it necessary to receive radiation for pT3-4N0 oral cancer without other adverse risk features?[J].ORAL DISEASES.2020,26(6):1124-1130.doi:10.1111/odi.13336.
APA：
Li Bo,Wang Chong,Yuan Xiaohong,Wang Zhen,Kim, Kyojin...&Feng Zhien.(2020).Is it necessary to receive radiation for pT3-4N0 oral cancer without other adverse risk features?.ORAL DISEASES,26,(6)
MLA：
Li Bo,et al."Is it necessary to receive radiation for pT3-4N0 oral cancer without other adverse risk features?".ORAL DISEASES 26..6(2020):1124-1130
