单位：[1]Department of Endocrinology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[2]Department of Endocrinology, Liaocheng People’s Hospital, Liaocheng, Shandong Province, China[3]Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China
Objective: To investigate if insulin resistance per se or the accompanying hyperinsulinemia induced hypertension and its underlying mechanisms. Methods: Sprague-Dawley rats were randomized into normal diet-fed group (ND group) and high-fat diet-fed group (HFD group). Then, the HFD group was further randomly divided into the control group (HFD_C group), the PIO group (treated with pioglitazone), the STZ_DM group (to induce diabetes with streptozotocin) and the DM+Ins group (streptozotocin injection followed by insulin treatment). Insulin sensitivity, plasma insulin, endothelin-1, norepinephrine, aldosterone, angiotensinII and 24-h urinary sodium excretion (USE) levels of the groups were measured and analyzed. A multiple stepwise regression analysis method was applied to exam our hypothesis. Results: Compared to HFD_C group, the groups with lower plasma insulin, the PIO group and STZ_DM group, showed higher USE and lower blood pressure. The groups with higher plasma insulin (but same level of insulin resistance), the HFD_C group and DM+Ins group, showed lower USE and higher blood pressure. The 24-h urinary sodium excretion was the most important contributor to the significant changes of blood pressure with an R-2 of 25.2% in this animal experiment. Conclusions: It is the compensatory hyperinsulinemia rather than insulin resistance per se that causes blood pressure elevation. The urinary sodium excretion is the key mediator among the multiple mechanisms. Therapies targeting hyperinsulinemia and restricting salt intake may favor a better control of hypertension associated with insulin resistance.
基金：
Clinical Research Institute of China-Japan Friendship Hospital
第一作者单位：[1]Department of Endocrinology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
通讯作者：
通讯机构：[1]Department of Endocrinology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[3]Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China[*1]Department of Endocrinology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 North Lishi Road, Xicheng District, Beijing 100037, China
推荐引用方式(GB/T 7714)：
Wang Hui,Tian Yaqiang,Chen Yanyan,et al.Hyperinsulinemia rather than insulin resistance itself induces blood pressure elevation in high fat diet-fed rats[J].CLINICAL and EXPERIMENTAL HYPERTENSION.2020,42(7):614-621.doi:10.1080/10641963.2020.1756316.
APA：
Wang, Hui,Tian, Yaqiang,Chen, Yanyan,Shen, Xiaoxia,Pan, Lin&Li, Guangwei.(2020).Hyperinsulinemia rather than insulin resistance itself induces blood pressure elevation in high fat diet-fed rats.CLINICAL and EXPERIMENTAL HYPERTENSION,42,(7)
MLA：
Wang, Hui,et al."Hyperinsulinemia rather than insulin resistance itself induces blood pressure elevation in high fat diet-fed rats".CLINICAL and EXPERIMENTAL HYPERTENSION 42..7(2020):614-621
