单位：[1]Department of Emergency Medicine, Beijing Chao-YangHospital, Capital Medical University, Beijing, China[2]Department of Critical Care Medicine, Peking UniversityThird Hospital, Beijing, China[3]Department of Emergency Medicine, Beijing FriendshipHospital, Capital Medical University, Beijing, China
Background The effect of steroid use on outcomes in patients with cardiac arrest (CA) remains controversial. We systematically reviewed the literature to investigate whether steroid use after CA increased the return of spontaneous circulation (ROSC) rate and survival to discharge in patients with CA. Methods PubMed, Embase, CNKI, and the Cochrane Central Register of Controlled Trials were searched for randomized controlled trials (RCTs) and observational studies on the effect of steroid use on outcomes in adults with CA. The outcomes were ROSC and survival to discharge. Results Seven studies (four RCTs and three observational studies) were included. Pooled analysis suggested that steroid use was associated with increased ROSC in patients with CA. Steroid use was significantly associated with survival to discharge, which was a consistent finding in RCTs and observational studies. Subgroup analysis based on the time of drug administration (during cardiopulmonary resuscitation [CPR] vs. after CA) showed that steroid use during CPR and after CA were significantly associated with an increased rate of ROSC and survival to discharge. Conclusion Current evidence indicates that steroid use after CA could increase ROSC and survival to discharge in patients with CA. However, high-quality and adequately powered RCTs are warranted.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2018]版：
Q4PHARMACOLOGY & PHARMACYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者单位：[1]Department of Emergency Medicine, Beijing Chao-YangHospital, Capital Medical University, Beijing, China
共同第一作者：
通讯机构：[*1]Department of Emergency Medicine, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong’an Road, Xicheng District, 100050 Beijing, China.
推荐引用方式(GB/T 7714)：
Liu Bo,Zhang Qiang,Li Chunsheng.Steroid use after cardiac arrest is associated with favourable outcomes: a systematic review and meta-analysis[J].JOURNAL of INTERNATIONAL MEDICAL RESEARCH.2020,48(5):doi:10.1177/0300060520921670.
APA：
Liu, Bo,Zhang, Qiang&Li, Chunsheng.(2020).Steroid use after cardiac arrest is associated with favourable outcomes: a systematic review and meta-analysis.JOURNAL of INTERNATIONAL MEDICAL RESEARCH,48,(5)
MLA：
Liu, Bo,et al."Steroid use after cardiac arrest is associated with favourable outcomes: a systematic review and meta-analysis".JOURNAL of INTERNATIONAL MEDICAL RESEARCH 48..5(2020)
