单位：[a]Department of Neurology, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, 100050, China临床科室神经内科神经内科首都医科大学附属北京友谊医院[b]Department of Neurology, The Fourth Central Hospital of Tianjin, 300140, China[c]Department of Neurology, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China[d]The Center for Translational Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, 116011, China大连医科大学附属第一医院[e]Department of Neurology, Methodist Neurological Institute, Prof. Neurology Weill Cornell Medical School, Houston, TX, USA
Background: Recent studies have suggested that cerebral ischemic infarction may contribute to the development of restless legs syndrome (RLS). This study analyzed the clinical and radiological profiles of RLS with onset after acute lacunar infarction. Methods: In this retrospective study we enrolled 244 consecutive patients with acute lacunar infarction between January 2012 and June 2014. RLS was identified and evaluated based on the International RLS Rating Scale (IRLS-RS). Individual sleep quality was assessed using the Epworth Sleepiness Scale (ESS). Psychological state was also assessed using the Hamilton Depression Scale (HDS) and the Hamilton Anxiety Scale (HAS). Results: The incidence of RLS in patients with lacunar infarction was 5.33%. Our participant group consisted of nine males and four females. Three patients had symptoms in bilateral limbs, and 10 patients had symptoms only contralateral to the cerebral infarction. The infarctions were localized to the pons, centrum semiovale, thalamus, putamen, medulla, and occipital lobe. Contralateral paralysis was found in 13 patients, and contralateral sensory deficit in seven patients. The average IRLS-RS, ESS, HDS, HAS scores were 19.07 +/- 8.70, 4.69 +/- 5.82, 4.38 +/- 4.68, and 3.85 +/- 4.76, respectively. Nine patients had diabetes mellitus. After administration of dopaminergic drugs, patients' RLS significantly improved. Conclusions: The incidence of RLS after acute lacunar infarction was 5.33%. Pons, centrum semiovale, and basal ganglia were the common locations of responsible lesions. Compared to idiopathic RLS, symptoms of RLS after acute lacunar infarction appeared more unilateral and more likely involved the arm. Moreover, diabetes mellitus may be a risk factor for RLS in stroke patients. (c) 2018 Elsevier B.V. All rights reserved.
基金：
Beijing Municipal Education CommissionBeijing Municipal Commission of Education [KM201610025016]
第一作者单位：[a]Department of Neurology, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, 100050, China[*1]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, 95 Yong’An Road, Xicheng District, Beijing, 100050, China.
共同第一作者：
通讯作者：
通讯机构：[a]Department of Neurology, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, 100050, China[e]Department of Neurology, Methodist Neurological Institute, Prof. Neurology Weill Cornell Medical School, Houston, TX, USA[*1]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, 95 Yong’An Road, Xicheng District, Beijing, 100050, China.[*2]Department of Neurology, Methodist Neurological Institute, Prof. Neurology Weill Cornell Medical School, Houston, TX, USA.
推荐引用方式(GB/T 7714)：
Houzhen Tuo,Zelong Tian,Xiaoyang Ma,et al.Clinical and radiological characteristics of restless legs syndrome following acute lacunar infarction[J].SLEEP MEDICINE.2019,53:81-87.doi:10.1016/j.sleep.2018.06.004.
APA：
Houzhen Tuo,Zelong Tian,Xiaoyang Ma,Yinong Cui,Yun Xue...&William Ondo.(2019).Clinical and radiological characteristics of restless legs syndrome following acute lacunar infarction.SLEEP MEDICINE,53,
MLA：
Houzhen Tuo,et al."Clinical and radiological characteristics of restless legs syndrome following acute lacunar infarction".SLEEP MEDICINE 53.(2019):81-87
