On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon alpha add-on therapy
单位：[1]Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases, Beijing, China临床科室国家中心肝病分中心首都医科大学附属北京友谊医院[2]Key Laboratory of Systems Biomedicine Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China[3]Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China[4]Department of Infectious Diseases, Affiliated Hospital of Yanbian University, Yanji, China[5]Department of Gastroenterology and Hepatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[6]Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China[7]Department of Digestive System, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[8]Hepatology Institute, Peking University People's Hospital, Beijing, China[9]Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China[10]Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China[11]Second Liver Cirrhosis Diagnosis and Treatment Center, Military Hospital of China, Beijing, China[12]Department of Infectious Disease, The Fifth Hospital of Shijiazhuang City, Shijiazhuang, China[13]Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital, Logistics University of People's Armed Police Force, Tianjin, China[14]Department of Gastroenterology and Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China[15]Department of Pathology, Beijing Youan Hospital, Capital Medical University, Beijing, China[16]Department of Pathology, China‐Japan Friendship Hospital, Beijing, China[17]Clinical Epidemiology and Evidence‐Based Medicine Unit, National Clinical Research Center for Digestive Diseases, Beijing, China首都医科大学附属北京友谊医院
Wisteria floribunda agglutinin-positive Mac-2-binding protein (M2BP) has been identified as a predictor for the response of interferon alpha (IFN-alpha) in patients with viral hepatitis. However, whether serum glycosylation isomer of M2BP (M2BPGi) was associated with the regression of liver fibrosis in patients with chronic hepatitis B (CHB) during IFN-alpha add-on therapy is still unknown. CHB patients were treated with entecavir for 26 weeks followed by entecavir plus pegylated IFN-alpha for 52 weeks. Liver biopsies were taken at baseline and treatment week 78. The regression of fibrosis was identified according to Ishak standard or Ishak plus Progressive-Indeterminate-Regressive (P-I-R) standard. Serum M2BPGi and liver function tests were measured at baseline and every 26 weeks of treatment. A total of 72 CHB patients were included in the present study. Serum M2BPGi was correlated with fibrosis and necroinflammation both at baseline and week 78. If Ishak standard was used as the reference, only the percent change of M2BPGi at week 52 from week 26 (Delta%M2BPGi(26w-52W)) was independently associated with fibrosis regression at treatment week 78, the area under the ROC curve (AUROC) of Delta%M2BPGi(26w-52W) for predicting fibrosis regression was 0.705. As for Ishak plus P-I-R standard, the AUROC of the predictive model for fibrosis regression (0.896*M2BPGi(52W) + 0.363*necroinflammation score(0w) + 2.051*Ishak score(0w) - 4.489) was 0.888. These data indicated that dynamic changes of serum M2BPGi were associated with fibrosis regression in CHB patients on IFN-alpha add-on therapy.
基金：
National Science and Technology Major Project [2018ZX10302204, 2013ZX10002004]; Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission [Z171100002217082, D161100002716003]
第一作者单位：[1]Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases, Beijing, China
通讯作者：
通讯机构：[1]Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases, Beijing, China[*1]Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center of Digestive Diseases, 95 Yongan Road, XiCheng District, Beijing 100050, China.
推荐引用方式(GB/T 7714)：
Liu Tianhui,Sun Yameng,Zhou Jialing,et al.On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon alpha add-on therapy[J].JOURNAL of MEDICAL VIROLOGY.2019,91(8):1499-1509.doi:10.1002/jmv.25465.
APA：
Liu, Tianhui,Sun, Yameng,Zhou, Jialing,Yang, Fang,Zou, Xia...&Jia, Jidong.(2019).On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon alpha add-on therapy.JOURNAL of MEDICAL VIROLOGY,91,(8)
MLA：
Liu, Tianhui,et al."On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon alpha add-on therapy".JOURNAL of MEDICAL VIROLOGY 91..8(2019):1499-1509
