单位：[1]School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China,[2]Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, China,[3]Department of Biomedical Engineering, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China,[4]Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China,[5]Guanganmen Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing, China,[6]Institute of Biological Chinese Medicine, Beijing Yichuang Institute of Biotechnology Industry, Beijing, China
Targeted drug delivery could increase the efficacy of chemotherapy, however, a plethora of obstacles exist in the current targeted delivery designs. In this study, we introduce a novel avenue of targeted drug delivery using electro-acupuncture and evaluate its effect on the distribution of paclitaxel in a breast cancer mouse model. Our results show that electro-acupuncture intervention significantly increased the intratumoral concentration of paclitaxel. The mice in acupuncture group showed shorter t(max), longer t(1/2) and higher AUC of paclitaxel as compared with that in paclitaxel-only group. Moreover, we found that the acupuncture intervention significantly induced cell apoptosis in tumors. The levels of COL IV and alpha-SMA increased in tumors of acupuncture group. The negative tumor metastasis biomarker, NM23, was significantly upregulated in tumors of mice in acupuncture group. Our results suggest that acupuncture intervention around the tumor area increases the local concentration of chemotherapeutic agents. The targeted effect of acupuncture is achieved by altering tumor microvasculature and microenvironment. Therefore, combined therapy of acupuncture with chemotherapeutic agents is promising in improving cancer treatment efficacy.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81573736]; Beijing Municipal Natural Science FoundationBeijing Natural Science Foundation [7172128]; Special Foundation for scientific research and development in Beijing University of Chinese Medicine Third Affiliated Hospital [2017-sykyfzzx-02]
第一作者单位：[1]School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China,
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Ming Yang,Yuxiang Wan,Xin Jiang,et al.Electro-Acupuncture Promotes Accumulation of Paclitaxel by Altering Tumor Microvasculature and Microenvironment in Breast Cancer of Mice[J].FRONTIERS in ONCOLOGY.2019,9:doi:10.3389/fonc.2019.00576.
APA：
Ming Yang,Yuxiang Wan,Xin Jiang,Xuewei Qi,Lina Wang...&Zenglin Lian.(2019).Electro-Acupuncture Promotes Accumulation of Paclitaxel by Altering Tumor Microvasculature and Microenvironment in Breast Cancer of Mice.FRONTIERS in ONCOLOGY,9,
MLA：
Ming Yang,et al."Electro-Acupuncture Promotes Accumulation of Paclitaxel by Altering Tumor Microvasculature and Microenvironment in Breast Cancer of Mice".FRONTIERS in ONCOLOGY 9.(2019)
