单位：[1]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050临床科室国家中心消化分中心消化内科首都医科大学附属北京友谊医院[2]Department of Gerontology, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012[3]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing 100050, P.R. China临床科室国家中心消化分中心消化内科首都医科大学附属北京友谊医院
Esophageal squamous cell cancer (ESCC) has a high mortality rate. MicroRNA (miR)-92a-3p is considered to be a tumor promotor and an oncomiR. The aim of the present study was to investigate the effect of miR-92a-3p and its target gene on ESCC in terms of proliferation, migration and invasion. Higher expression of miR-92a-3p was detected in the tissues of patients with ESCC, compared with that in normal tissues. In addition, ESCC cell lines had a higher expression of miR-92a-3p compared with normal esophageal cells. A miR-92a-3p mimic was found to promote ESCC cell proliferation and a miR-92a-3p inhibitor was found to reduce ESCC cell proliferation. miR-92a-3p mimic transfection accelerated ESCC cell migration and invasion and decreased ESCC cell apoptosis via the Bax/Bcl-2 pathway and cleaved caspase-3. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was detected as a target of miR-92a-3p by a dual luciferase reporter assay. The overexpression of PTEN not only inhibited ESCC proliferation, migration and invasion, but also promoted ESCC cell apoptosis. PTEN and the miR-92a-3p mimic inhibited and promoted ESCC proliferation, respectively, which may be associated with the PI3K/Akt pathway. The results of the study revealed that miR-92a-3p promoted the proliferation, migration and invasion of ESCC, and the effect of miR-92a-3p on ESCC was realized by regulating PTEN.
第一作者单位：[1]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050[2]Department of Gerontology, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012
通讯作者：
通讯机构：[3]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing 100050, P.R. China[*1]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, 95 Yong'an Road, Beijing 100050, P.R. China
推荐引用方式(GB/T 7714)：
Li Xin,Guo Shuilong,Min Li,et al.miR-92a-3p promotes the proliferation, migration and invasion of esophageal squamous cell cancer by regulating PTEN[J].INTERNATIONAL JOURNAL of MOLECULAR MEDICINE.2019,44(3):973-981.doi:10.3892/ijmm.2019.4258.
APA：
Li, Xin,Guo, Shuilong,Min, Li,Guo, Qingdong&Zhang, Shutian.(2019).miR-92a-3p promotes the proliferation, migration and invasion of esophageal squamous cell cancer by regulating PTEN.INTERNATIONAL JOURNAL of MOLECULAR MEDICINE,44,(3)
MLA：
Li, Xin,et al."miR-92a-3p promotes the proliferation, migration and invasion of esophageal squamous cell cancer by regulating PTEN".INTERNATIONAL JOURNAL of MOLECULAR MEDICINE 44..3(2019):973-981
