单位：[1]Department of Pathology, Affiliated Hospital of Nantong University,Nantong 226001, People’s Republic of China[2]Department of Pathology,Beijing Friendship Hospital, Capital Medical University, Beijing 100000,People’s Republic of China医技科室病理科病理科首都医科大学附属北京友谊医院
Background To evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL). Methods LMO2 and CD38 expression determined by immunohistochemistry in 75 BL, 12 High-grade B-cell lymphoma, NOS (HGBL,NOS) and 3 Burkitt-like lymphomas with the 11q aberration. Results The sensitivity and specificity of LMO2 negative for detecting BL were 98.67 and 100%, respectively; those of CD38 positive were 98.67 and 66.67%, respectively. The sensitivity and specificity of a combination of both for detecting BL were 97.33 and 100%, respectively. In our study, the combined LMO2 negative and CD38 positive results had a higher area under the curve than either LMO2 negative or CD38 positive alone. Conclusions A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma.
基金：
Six Talent Peaks Project in Jiangsu Province, China [WSN-059]; Scientific Research Topic of Jiangsu Provincial Health and Family Planning Commission, China [H201626]; Key Talents of Medical Science in Jiangsu Province, China [QNRC2016682]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81602010]; Key Scientific and Technological Projects in Nantong City, Jiangsu, China [MS22018001]; Jiangsu Postdoctoral Foundation Research Project, China [2019Z142]
第一作者单位：[1]Department of Pathology, Affiliated Hospital of Nantong University,Nantong 226001, People’s Republic of China
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推荐引用方式(GB/T 7714)：
Liu Yifei,Bian Tingting,Zhang Yanlin,et al.A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma[J].DIAGNOSTIC PATHOLOGY.2019,14(1):doi:10.1186/s13000-019-0876-3.
APA：
Liu, Yifei,Bian, Tingting,Zhang, Yanlin,Zheng, Yuanyuan,Zhang, Jianguo...&Xie, Jianlan.(2019).A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma.DIAGNOSTIC PATHOLOGY,14,(1)
MLA：
Liu, Yifei,et al."A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma".DIAGNOSTIC PATHOLOGY 14..1(2019)
