单位：[1]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China临床科室国家中心普外分中心普外五科（综合普外科）首都医科大学附属北京友谊医院[2]Department of Breast Surgery Ward No. 3, The Affiliated Tumor Hospital of Shanxi Medical University, Shanxi Tumor Hospital, Taiyuan, Shanxi, China
Objective This study aimed to investigate the clinicopathological factors of the false negative rate (FNR) and accuracy of sentinel lymph node biopsy (SLNB) mapping with 1% methylene blue dye (MBD) alone, and to examine how to reduce the FNR in patients with breast cancer. Methods A total of 365 patients with invasive breast carcinoma who received axillary lymph node dissection after SLNB were retrospectively analyzed. SLNB was performed with 2 to 5 mL of 1% MBD. We studied the clinicopathological factors that could affect the FNR of SLNB. Results The identification rate of sentinel lymph nodes (SLNs) was 98.3% (359/365) and the FNR of SLNB was 10.4% (16/154). Multivariate analysis showed that the number of dissected SLNs and metastatic lymph nodes were independent predictive factors for the FNR of SLNB. The FNR in patients with 1, 2, 3, and >= 4 SLNs was 23.53%, 15.79%, 3.85%, and 1.79%, respectively. Conclusions SLNB mapping with MBD alone in patients with breast cancer can produce favorable identification rates. The FNR of SLNB decreases as the number of SLNs rises. Because of side effects of searching for additional SLNs and the FNR, removal of three or four SLNs may be appropriate.
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2017]版：
Q4PHARMACOLOGY & PHARMACYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者单位：[1]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China[2]Department of Breast Surgery Ward No. 3, The Affiliated Tumor Hospital of Shanxi Medical University, Shanxi Tumor Hospital, Taiyuan, Shanxi, China
通讯作者：
通讯机构：[1]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China[*1]Department of general surgery, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Road, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Huang Li,Zhang Jun,Ge Zhi-Cheng,et al.Factors that affect the false negative rate of sentinel lymph node mapping with methylene blue dye alone in breast cancer[J].JOURNAL of INTERNATIONAL MEDICAL RESEARCH.2019,47(10):4841-4853.doi:10.1177/0300060519827413.
APA：
Huang, Li,Zhang, Jun,Ge, Zhi-Cheng&Qu, Xiang.(2019).Factors that affect the false negative rate of sentinel lymph node mapping with methylene blue dye alone in breast cancer.JOURNAL of INTERNATIONAL MEDICAL RESEARCH,47,(10)
MLA：
Huang, Li,et al."Factors that affect the false negative rate of sentinel lymph node mapping with methylene blue dye alone in breast cancer".JOURNAL of INTERNATIONAL MEDICAL RESEARCH 47..10(2019):4841-4853
