单位：[1]Traditional Chinese Medicine Hospital of Changping District, Beijing 102200, China[2]Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China[3]Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China[4]Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100070, China[5]Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100070, China
Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of Tand B cells; ratio of Tcell subsets; inflammatory response of monocytes, macrophages, and immunoglobulins; and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81673844, 81573845, 81373773, 81760838]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7142144]; China Scholarship Council FundChina Scholarship Council [201609110029]; International Cooperation Project of the State Administration of Traditional Chinese Medicine [GZYYGJ2017014]; International Cooperation Project of the Ministry of Science and Technology [2014DFA31490]
第一作者单位：[1]Traditional Chinese Medicine Hospital of Changping District, Beijing 102200, China[2]Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China
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推荐引用方式(GB/T 7714)：
Dan Luo,Zhengyun Zuo,Hongyan Zhao,et al.Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice[J].FRONTIERS of MEDICINE.2019,13(5):556-563.doi:10.1007/s11684-018-0649-5.
APA：
Dan Luo,Zhengyun Zuo,Hongyan Zhao,Yong Tan&Cheng Xiao.(2019).Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice.FRONTIERS of MEDICINE,13,(5)
MLA：
Dan Luo,et al."Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice".FRONTIERS of MEDICINE 13..5(2019):556-563
