单位：[1]Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, China,[2]Institute of Plant Resources, Yunnan University, Kunming, China,[3]Department of Emergency, China-Japan Friendship Hospital, Beijing, China
Tripterygium wilfordii Hook. f. (TWHF) is a traditional Chinese herbal medicine and widely used to treat diabetic kidney disease in China. Emerging evidences have revealed its ability to attenuate diabetic nephropathy (DN). Tripterygium wilfordii polyglycosides (TWPs), triptolide (TP), and celastrol are predominantly active compounds isolated from TWHF. The effects and molecular mechanisms of TWHF and its active compounds have been investigated in recent years. Currently, it is becoming clearer that the effects of TWHF and its active compounds involve in anti-inflammation, anti-oxidative stress, anti-fibrosis, regulating autophagy, apoptosis, and protecting podocytes effect. This review presents an overview of the current findings related to the effects and mechanisms of TWHF and its active compounds in therapies of DN, thus providing a systematic understanding of the mechanisms and therapeutic targets by which TWHF and its active compounds affect cells and tissues in vitro and in vivo.
基金：
Research Projects of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81904174]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2021M693579]; National Training Program for Innovative Key Talents of Traditional Chinese Medicine [2019-128]
第一作者单位：[1]Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, China,
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Peng,Zhang Jing,Wang Yun,et al.The Active Compounds and Therapeutic Target of Tripterygium wilfordii Hook. f. in Attenuating Proteinuria in Diabetic Nephropathy: A Review[J].FRONTIERS in MEDICINE.2021,8:doi:10.3389/fmed.2021.747922.
APA：
Liu, Peng,Zhang, Jing,Wang, Yun,Shen, Zhengri,Wang, Chen...&Qiu, Xinping.(2021).The Active Compounds and Therapeutic Target of Tripterygium wilfordii Hook. f. in Attenuating Proteinuria in Diabetic Nephropathy: A Review.FRONTIERS in MEDICINE,8,
MLA：
Liu, Peng,et al."The Active Compounds and Therapeutic Target of Tripterygium wilfordii Hook. f. in Attenuating Proteinuria in Diabetic Nephropathy: A Review".FRONTIERS in MEDICINE 8.(2021)
