单位：[1]Medical faculty of Hubei Polytechnic Institute, Xiaogan, Hubei, China[2]St Claraspital Hospital, CH-4058, Basel, Switzerland[3]Department of Obstetrics and Gynecology, China Meitan General Hospital, Beijing, China[4]Department of Obstetrics and Gynecology, Suzhou Municipal Hospital, Jiangsu, China[5]Department of Obstetrics and Gynecology, Jingmen No.1 People’s Hospital, Hubei, China[6]Wuhan No.5 Hospital, Wuhan, Hubei, China[7]Department of Obstetrics and Gynaecology, China-Japan Friendship Hospital, Beijing, China[8]Clinical Center, National Institutes of Health, Bethesda, MD, USA
Ovarian cancer (OC) is the most lethal gynecologic cancer, and the incidence of OC has risen steadily worldwide. Numerous microRNAs (miRNAs) have been found to be involved in the progression of OC. miR-204-5p is down-regulated and functions as a tumor suppressor in various types of human malignant tumors. However, the biological roles and molecular mechanisms of miR-204-5p in OC still remain unclear. In this study, the aberrant down-regulation of miR-204-5p was detected in OC tissues. We also observed that miR-204-5p overexpression represses OC cell proliferation. Ubiquitin-specific peptidase 47 (USP47) is verified as the functional target of miR-204-5p, through which it plays an important biological role in OC. Our results uncover new functions and mechanisms for miR-204-5p in the progression of OC, and provide a potential therapeutic target for the treatment of OC.
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外文
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出版当年[2018]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区移植4 区细胞与组织工程
最新[2025]版：
大类|4 区医学
小类|3 区移植4 区细胞与组织工程4 区医学：研究与实验
JCR分区：
出版当年[2017]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2TRANSPLANTATIONQ3CELL & TISSUE ENGINEERING
最新[2023]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2TRANSPLANTATIONQ3CELL & TISSUE ENGINEERING
