单位：[1]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.临床科室神经内科神经内科首都医科大学附属北京友谊医院[2]Department of Geriatric Neurology, Chinese People’s Liberation Army General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing 100853, China.[3]Department of Neurology and Center for Translational Neuromedicine, University of Rochester Medical Center, New York, NY, USA.
Background Nocardiosis is a rare and life-threatening opportunistic infection in immunocompromised patients. Myasthenia gravis (MG) patients are potentially at risk of nocardia infection because of the use of immunosuppressive agents. To date, only 7 patients with MG have been reported to have nocardiosis. Disseminated nocardiosis with ocular involvement has not been reported in MG patients. Case presentation A 66-year-old man with MG who was receiving treatment with methylprednisolone and azathioprine was found to have a respiratory infection. He also had heterogeneous symptoms with skin, brain and ocular manifestations. Nocardia bacteria verified by the culture of puncture fluid, and a diagnosis of disseminated nocardiosis was made. Except for left eye blindness, the patient completely recovered from the disease with combination antibiotic therapy. To further understand nocardiosis in patients with MG, we reviewed the previous relevant literature. According to the literature, this is the first report of disseminated nocardiosis with ocular involvement in an MG patient. Conclusions MG patients with immunosuppressant treatments are potentially at risk of a rare nocardia infection, and a favourable prognosis can be achieved through early diagnosis and appropriate antibiotic therapy.
基金：
Research Foundation of Beijing Friendship Hospital, Capital Medical University [yyqdkt2018-30]
第一作者单位：[1]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Shuhui Wang,Bin Jiang,Yao Li,et al.A case report of disseminated nocardiosis with ocular involvement in a myasthenia gravis patient and literature review[J].BMC NEUROLOGY.2019,19(1):doi:10.1186/s12883-019-1482-4.
APA：
Shuhui Wang,Bin Jiang,Yao Li,Yanchang Shang,Zhengshan Liu&Yongbo Zhang.(2019).A case report of disseminated nocardiosis with ocular involvement in a myasthenia gravis patient and literature review.BMC NEUROLOGY,19,(1)
MLA：
Shuhui Wang,et al."A case report of disseminated nocardiosis with ocular involvement in a myasthenia gravis patient and literature review".BMC NEUROLOGY 19..1(2019)
