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FOXJ1 promotes bladder cancer cell growth and regulates Warburg effect

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收录情况： ◇ SCIE

作者：

单位： [a]Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China [b]Department of Urology, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China

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关键词： FOXJ1 Bladder cancer Aerobic glycolysis Tumor growth

摘要：

Forkhead Box J1 (FOXJ1) which belongs to Fox gene family, plays complex and crucial roles in processes of development, organogenesis, regulation of the immune system, as well as progression of several malignancies. However, how FOXJ1 functions in bladder cancer remains unclear. Here, we report that FOXJ1 is upregulated in most bladder cancer patients, and predicts poor clinical outcomes. FOXJ1 facilitates bladder cancer cell proliferation and colony formation. FOXJ1 knockdown suppresses bladder tumor growth in nude mice. Mechanistically, FOXJ1 enhances glycolysis by increasing glucose uptake, lactate production and extracellular acidification rate (ECAR), and decreasing ATP generation and oxygen consumption rate (OCR) in bladder cancer cells. Our findings provide clues regarding the role of FOXJ1 as a tumor inducer in bladder cancer and an enhancer in glycolysis. Targeting FOXJ1 could be a potential therapeutic strategy in bladder cancer. (C) 2017 Elsevier Inc. All rights reserved.

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中科院(CAS)分区：

出版当年[2017]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学 4 区生物物理

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区生物物理

JCR分区：

出版当年[2016]版：

Q3 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 2.5 最新五年平均[2021-2025] 2.7 出版当年[2016版] 2.466 出版当年五年平均[2012-2016] 2.354 出版前一年[2015版] 2.371 出版后一年[2017版] 2.559

第一作者：

第一作者单位： [a]Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China [b]Department of Urology, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China

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