单位：[1]Department of Biomedical Engineering, Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China.[2]Department of Hepatobiliary Surgery, China-Japan Friendship Hospital, Beijing, China.[3]Department of Radiology, China-Japan Friendship Hospital, Beijing, China.[4]Philips Research China, Shanghai, China.[5]Philips Research, Hamburg, Germany.[6]Philips Healthcare, Best, the Netherlands.[7]Department of Radiology, University of Washington, Seattle, Washington, USA.
PurposeTo propose a simultaneous acquisition sequence for improved hepatic pharmacokinetics quantification accuracy (SAHA) method for liver dynamic contrast-enhanced MRI. MethodsThe proposed SAHA simultaneously acquired high temporal-resolution 2D images for vascular input function extraction using Cartesian sampling and 3D large-coverage high spatial-resolution liver dynamic contrast-enhanced images using golden angle stack-of-stars acquisition in an interleaved way. Simulations were conducted to investigate the accuracy of SAHA in pharmacokinetic analysis. A healthy volunteer and three patients with cirrhosis or hepatocellular carcinoma were included in the study to investigate the feasibility of SAHA in vivo. ResultsSimulation studies showed that SAHA can provide closer results to the true values and lower root mean square error of estimated pharmacokinetic parameters in all of the tested scenarios. The in vivo scans of subjects provided fair image quality of both 2D images for arterial input function and portal venous input function and 3D whole liver images. The in vivo fitting results showed that the perfusion parameters of healthy liver were significantly different from those of cirrhotic liver and HCC. ConclusionsThe proposed SAHA can provide improved accuracy in pharmacokinetic modeling and is feasible in human liver dynamic contrast-enhanced MRI, suggesting that SAHA is a potential tool for liver dynamic contrast-enhanced MRI. Magn Reson Med 79:2629-2641, 2018. (c) 2017 International Society for Magnetic Resonance in Medicine.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81371540, 81571667]
第一作者单位：[1]Department of Biomedical Engineering, Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China.
通讯作者：
通讯机构：[1]Department of Biomedical Engineering, Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China.[*1]Department of Biomedical Engineering, Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing 100084, China.
推荐引用方式(GB/T 7714)：
Ning Jia,Sun Yongliang,Xie Sheng,et al.Simultaneous acquisition sequence for improved hepatic pharmacokinetics quantification accuracy (SAHA) for dynamic contrast-enhanced MRI of liver[J].MAGNETIC RESONANCE in MEDICINE.2018,79(5):2629-2641.doi:10.1002/mrm.26915.
APA：
Ning, Jia,Sun, Yongliang,Xie, Sheng,Zhang, Bida,Huang, Feng...&Chen, Huijun.(2018).Simultaneous acquisition sequence for improved hepatic pharmacokinetics quantification accuracy (SAHA) for dynamic contrast-enhanced MRI of liver.MAGNETIC RESONANCE in MEDICINE,79,(5)
MLA：
Ning, Jia,et al."Simultaneous acquisition sequence for improved hepatic pharmacokinetics quantification accuracy (SAHA) for dynamic contrast-enhanced MRI of liver".MAGNETIC RESONANCE in MEDICINE 79..5(2018):2629-2641
医学