单位：[1]Department of Orthopedic Surgery, China-Japan Friendship Institute of Clinical Medicine, Peking Union Medical College, Beijing 100029, China[2]Centre for Osteonecrosis and Joint-Preserving & Reconstruction, Department of Orthopedic Surgery, Beijing Key Laboratory of Arthritic and Rheumatic Diseases, China-Japan Friendship Hospital, Peking Union Medical College, National Health and Family Planning Commission of the People’s Republic of China, Beijing 100029, China[3]Department of Orthopedic Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China
Steroid-induced osteonecrosis of the femoral head (ONFH) has the incidence of 9-40% in patients receiving long-term treatment and is mainly involved in the middle and young people. It is mostly bilateral, with a wide range of necrosis and high disability rate, which brings disaster for patients and families. The experimental study shows that autophagy participates in the pathological process of steroid ONFH and is closely related to apoptosis, and the interaction between autophagy and bone cells is related to the dose of hormones. Moreover, autophagy also affects the interaction between osteoblasts and osteoclasts in ONFH. In the present review, we have discussed the role of autophagy in the pathological process of the steroid-induced ONFH.
基金：
Beijing Natural Science FoundationBeijing Natural Science Foundation [7174346]; Capital's Funds for Health Improvement and Research [CFH2018-4-40611]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372013, 81672236]
第一作者单位：[1]Department of Orthopedic Surgery, China-Japan Friendship Institute of Clinical Medicine, Peking Union Medical College, Beijing 100029, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Orthopedic Surgery, China-Japan Friendship Institute of Clinical Medicine, Peking Union Medical College, Beijing 100029, China[2]Centre for Osteonecrosis and Joint-Preserving & Reconstruction, Department of Orthopedic Surgery, Beijing Key Laboratory of Arthritic and Rheumatic Diseases, China-Japan Friendship Hospital, Peking Union Medical College, National Health and Family Planning Commission of the People’s Republic of China, Beijing 100029, China[3]Department of Orthopedic Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Luo Pan,Gao Fuqiang,Han Jun,et al.The role of autophagy in steroid necrosis of the femoral head: a comprehensive research review[J].INTERNATIONAL ORTHOPAEDICS.2018,42(7):1747-1753.doi:10.1007/s00264-018-3994-8.
APA：
Luo, Pan,Gao, Fuqiang,Han, Jun,Sun, Wei&Li, Zirong.(2018).The role of autophagy in steroid necrosis of the femoral head: a comprehensive research review.INTERNATIONAL ORTHOPAEDICS,42,(7)
MLA：
Luo, Pan,et al."The role of autophagy in steroid necrosis of the femoral head: a comprehensive research review".INTERNATIONAL ORTHOPAEDICS 42..7(2018):1747-1753
