单位：[1]State Key Laboratory of Chemical Resource, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China[2]Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China[3]College of Science, Beijing University of Chemical Technology, Beijing, China
The response to temperature and glucose, high salt tolerance and self-regulated drug delivery are simultaneously probable by applying a multifunctional microgel in a rational design by a colloid chemistry method. Such smart microgels were fabricated with thermoresponsive N-isopropylacrylamide, glucose-sensitive (2-phenylboronic esters-1,3-dioxane-5-ethyl)methyl acrylate (PBDEMA) and water-soluble crosslinker poly(ethylene glycol) diacrylate through a precipitation emulsion method. These colloidal nanoparticles exhibited PBDEMA-composition-dependent responsive behavior with changing temperature and ionic strength. Amongst them, the microgel with 20.7 mol% PBDEMA with a narrow size distribution is suitable for diabetes treatment because it can adapt to the surrounding medium of different glucose concentrations over a clinically relevant range (0-2.0 mg mL(-)(1)), control the release of preloaded insulin and is highly stable under normal physiological conditions. Preliminary experiments suggest these highly stable microgels have the potential to be used for self-regulated therapy and monitoring the response to treatment. (C) 2018 Society of Chemical Industry
基金：
National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [21374005, U1663227]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [PYBZ1702]; Beijing National Laboratory for Molecular Sciences [BNLMS20150127]
第一作者单位：[1]State Key Laboratory of Chemical Resource, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
通讯作者：
通讯机构：[1]State Key Laboratory of Chemical Resource, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China[2]Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China[*1]Department of Endocrinology, China-Japan Friendship Hospital, Beijing 100029, China[*2]State Key Laboratory of Chemical Resource, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Gu Shiling,Yang Liu,Li Shirui,et al.Thermo- and glucose-sensitive microgels with improved salt tolerance for controlled insulin release in a physiological environment[J].POLYMER INTERNATIONAL.2018,67(9):1256-1265.doi:10.1002/pi.5634.
APA：
Gu, Shiling,Yang, Liu,Li, Shirui,Yang, Junjiao,Zhang, Bo&Yang, Jing.(2018).Thermo- and glucose-sensitive microgels with improved salt tolerance for controlled insulin release in a physiological environment.POLYMER INTERNATIONAL,67,(9)
MLA：
Gu, Shiling,et al."Thermo- and glucose-sensitive microgels with improved salt tolerance for controlled insulin release in a physiological environment".POLYMER INTERNATIONAL 67..9(2018):1256-1265
