单位：[1]Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China[2]China Japan Friendship Hosp, Dept Dermatol, East St Cherry Pk, Beijing 100029, Peoples R China[3]Peking Union Med Coll & Chinese Acad Med Sci, Grad Sch, Beijing 100730, Peoples R China
Dissolving microneedle patch (DMNP) is a minimally invasive and painless self-administration device. However, due to skin deformation, it is difficult to apply it on the large areas of skin or curved skin as the patch size increased for DMNP. Here, we propose a polyvinyl alcohol (PVA)-based dissolving microneedle roller ( DMNR) device that can be used for delivering drugs rapidly on the large surface areas or curved skin and does not need to be attached on the skin all the time during drug delivery. The hypoglycemic effect of insulin-loaded DMNRs for transdermal delivery of insulin was studied on the type 1 diabetic rat models. It was found that the insulin-loaded DMNR has an immediate and effective hypoglycemic effect that the blood glucose level reduced below to 50% of original blood glucose at 1 h after DMNRs administrated.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51873015]; Joint Project of BRC-BC (Biomedical Translational Engineering Research Center of BUCT-CJFH) [XK2020-05, RZ2020-01]; Ministry of Finance of PRC; Ministry of Education of PRCMinistry of Education, China
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2021]版：
大类|3 区医学
小类|2 区药学3 区医学：研究与实验
最新[2025]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区药学
JCR分区：
出版当年[2020]版：
Q2PHARMACOLOGY & PHARMACYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者单位：[1]Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Xiao Peng,Zhang Bao Li,Chen Bo Zhi,et al.Dissolving microneedle rollers for rapid transdermal drug delivery[J].DRUG DELIVERY and TRANSLATIONAL RESEARCH.2022,12(2):459-471.doi:10.1007/s13346-021-01048-8.
APA：
Zhang, Xiao Peng,Zhang, Bao Li,Chen, Bo Zhi,Zhao, Ze Qiang,Fei, Wen Min...&Guo, Xin Dong.(2022).Dissolving microneedle rollers for rapid transdermal drug delivery.DRUG DELIVERY and TRANSLATIONAL RESEARCH,12,(2)
MLA：
Zhang, Xiao Peng,et al."Dissolving microneedle rollers for rapid transdermal drug delivery".DRUG DELIVERY and TRANSLATIONAL RESEARCH 12..2(2022):459-471
