单位：[1]College of Science, Beijing University of Chemical Technology, Beijing, 100029, China[2]Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, Beijing University of Chemical Technology, Beijing, 100029, China[3]Cardiac Department of Internal Medicine, China-Japan Friendship Hospital, Beijing, 100029, China
The objective of this study was to test whether dual-frequency ultrasound could enhance the efficacy of sonophoresis and whether the enhanced effect of dual-frequency was additive or synergistic. The enhancing percutaneous permeability of sinomenine hydrochloride was studied and the mechanism behind transdermal delivery enhancement via dual-frequency sonophoresis was analyzed by employing dual-frequency of 20 kHz and 800 kHz. In order to simultaneously use two ultrasound probes with different frequencies to pre-treat skin and carry out permeation experiment in the same apparatus, an improved Franz diffusion cell was designed. In comparison to single-frequency (20 kHz or 800 kHz) ultrasound, the effect of dual-frequency (20 kHz + 800 kHz) ultrasound on transdermal permeation of sinomenine hydrochloride was studied. Experiments showed that using dual-frequency ultrasound, the 12-h permeability of sinomenine hydrochloride was greater than the sum of that compared to 20 kHz and 800 kHz single-frequency samples respectively. In addition, dual-frequency pretreatment could reduce minimum threshold. dose of pretreatment time in this experiment. The experimental results indicated that dual-frequency ultrasound could be more efficient in enhancing transdermal and topical delivery of sinomenine hydrochloride when compared with single-frequency ultrasound and improving transdermal delivery is due to synergistic effect instead of simple energy superposition. (C) 2016 Elsevier B.V. All rights reserved.
第一作者单位：[1]College of Science, Beijing University of Chemical Technology, Beijing, 100029, China[2]Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, Beijing University of Chemical Technology, Beijing, 100029, China
通讯作者：
通讯机构：[1]College of Science, Beijing University of Chemical Technology, Beijing, 100029, China[2]Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, Beijing University of Chemical Technology, Beijing, 100029, China[*1]College of Science, Beijing University of Chemical Technology, Beijing, 100029, China
推荐引用方式(GB/T 7714)：
Yin L.,Qin F. H.,Zhou Y.,et al.Enhancing percutaneous permeability of sinomenine hydrochloride using dual-frequency sonophoresis[J].JOURNAL of DRUG DELIVERY SCIENCE and TECHNOLOGY.2016,36:62-67.doi:10.1016/j.jddst.2016.09.009.
APA：
Yin, L.,Qin, F. H.,Zhou, Y.&Qi, X..(2016).Enhancing percutaneous permeability of sinomenine hydrochloride using dual-frequency sonophoresis.JOURNAL of DRUG DELIVERY SCIENCE and TECHNOLOGY,36,
MLA：
Yin, L.,et al."Enhancing percutaneous permeability of sinomenine hydrochloride using dual-frequency sonophoresis".JOURNAL of DRUG DELIVERY SCIENCE and TECHNOLOGY 36.(2016):62-67
