单位：[1]Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 10029, Peoples R China[2]Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China[3]China Japan Friendship Hosp, Dept Dermatol, East St Cherry Pk, Beijing 100029, Peoples R China[4]Beijing Univ Chem Technol, High Tech Res Inst, Beijing, Peoples R China
In this study, we reported two types of PMNs based on polylactic acid (PLA) and polyvinyl alcohol (PVA), respectively. Parafilm M (R) film, porcine skin, and rats & rsquo; models were operated to evaluate the mechanical properties in vitro and in vivo to find optimal parameters for efficient insertion. Insertion depth was mea-sured using Digital Force Gauge by changing insertion force and speed, respectively. Results showed that increasing the insertion force and speed used for PMNs application led to a significant increase in the depth of insertion. A force of 18 N under a speed of 330 mm/min was the optimal condition for inserting PMNs array into Parafilm M (R) film and porcine skin. In addition, PLA-MNs exhibited higher robustness and enhanced homogeneity in insertion depth compared with PVA-MNs, but PVA-MNs were able to reach much deeper insertion depth. Moreover, Sprague Dawley (SD) rat experiments confirmed the effective-ness of optimal insertion parameters for transdermal drug delivery. This study illustrated not only the development of novel PMNs but also the mechanical evaluation for the design of PMNs. (c) 2022 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. <comment>Superscript/Subscript Available</comment
第一作者单位：[1]Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 10029, Peoples R China[2]Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 10029, Peoples R China[2]Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China[3]China Japan Friendship Hosp, Dept Dermatol, East St Cherry Pk, Beijing 100029, Peoples R China[4]Beijing Univ Chem Technol, High Tech Res Inst, Beijing, Peoples R China[*1]Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China[*2]State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 10029, PR China
推荐引用方式(GB/T 7714)：
Liu Rui Xuan,He Yu Ting,Liang Ling,et al.Mechanical evaluation of polymer microneedles for transdermal drug delivery: In vitro and in vivo[J].JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY.2022,114:181-189.doi:10.1016/j.jiec.2022.07.008.
APA：
Liu, Rui Xuan,He, Yu Ting,Liang, Ling,Hu, Liu Fu,Liu, Yue...&Guo, Xin Dong.(2022).Mechanical evaluation of polymer microneedles for transdermal drug delivery: In vitro and in vivo.JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY,114,
MLA：
Liu, Rui Xuan,et al."Mechanical evaluation of polymer microneedles for transdermal drug delivery: In vitro and in vivo".JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY 114.(2022):181-189
