单位：[1]Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China[2]Department of Dermatology, China-Japan Friendship Hospital, East Street Cherry Park, Chaoyang District, Beijing, 100029, PR China
As an approach of transdermal drug delivery, coated microneedles (MNs) have received extensive attention. Dipcoating method is a commonly used method in the preparation of coated MNs, due to its simple fabrication process and low cost. In this work, we proposed four different coating methods based on the dip-coating process, including dip-coating with a dam board, a roller, a fixture and a limit. The drug loading of the single MN prepared from the four methods was not significant (p > 0.05), from 15 to 16 ng. The minimum deviation of drug loading achieved 12.3% from the fixture device method. The in vitro drug delivery was also evaluated and the results revealed that the MNs fabricated from all methods could achieve about 90% drug delivery efficiency. All the results demonstrated that the dip-coating with a fixture method could guarantee a better homogeneous drug loading, which may be potential for future large-scale production of drug coated MNs.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51673019, 51873015]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [PYBZ1817]; Research projects on biomedical transformation of China-Japan Friendship Hospital [PYBZ1817]; Ministry of Finance of PRC; Ministry of Education of PRCMinistry of Education, China
第一作者单位：[1]Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China
通讯作者：
通讯机构：[1]Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China[*1]Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China.
推荐引用方式(GB/T 7714)：
Liang Ling,Chen Yang,Zhang Bao Li,et al.Optimization of dip-coating methods for the fabrication of coated microneedles for drug delivery[J].JOURNAL of DRUG DELIVERY SCIENCE and TECHNOLOGY.2020,55:doi:10.1016/j.jddst.2019.101464.
APA：
Liang, Ling,Chen, Yang,Zhang, Bao Li,Zhang, Xiao Peng,Liu, Jing Ling...&Guo, Xin Dong.(2020).Optimization of dip-coating methods for the fabrication of coated microneedles for drug delivery.JOURNAL of DRUG DELIVERY SCIENCE and TECHNOLOGY,55,
MLA：
Liang, Ling,et al."Optimization of dip-coating methods for the fabrication of coated microneedles for drug delivery".JOURNAL of DRUG DELIVERY SCIENCE and TECHNOLOGY 55.(2020)
