单位：[a]Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China[b]Key Laboratory of Biomedical Materials of Natural Macromolecules, Beijing University of Chemical Technology, Ministry of Education, Beijing 100029, China[c]Department of Dermatology, China-Japan Friendship Hospital, East Street Cherry Park, Chaoyang District, Beijing 100029, China[d]Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
In recent years, applications of microneedle (MN) technology in medical health sensing devices and platforms have been developed due to its advantages of minimal invasiveness, real-time, and convenience. Electrochemical biosensors and interstitial fluid (ISF) direct extraction are two types of MN based technologies applied in medical sensing. In MN based electrochemical biosensors, conducting polymers (CPs), enzymes, nanoparticles, and their composites are used to modify MN electrodes to selectively monitor glucose, lactate, alcohol, urea, amino acids, therapeutic drugs, or bio-signals recording. In MN based ISF direct extraction for further sensing, silicon, silicon oxide, and some polymers are introduced to the fabrication of hollow or hydrogel MNs. These two types of MN based technologies were employed in glucose monitoring, therapeutic drug monitoring (TDM), protein analysis, etc. This review is to present the development and application of MN based technologies on electrochemical biosensors and ISF direct extraction and also to describe some prospects and limitations on medical sensing.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51873015]; Joint Project of BRC-BC (Biomedical Translational Engineering Research Center of BUCTCJFH) [XK2020-05]; Ministry of Finance; Ministry of Education of PRCMinistry of Education, China
第一作者单位：[a]Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China[b]Key Laboratory of Biomedical Materials of Natural Macromolecules, Beijing University of Chemical Technology, Ministry of Education, Beijing 100029, China
通讯作者：
通讯机构：[a]Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China[b]Key Laboratory of Biomedical Materials of Natural Macromolecules, Beijing University of Chemical Technology, Ministry of Education, Beijing 100029, China[c]Department of Dermatology, China-Japan Friendship Hospital, East Street Cherry Park, Chaoyang District, Beijing 100029, China[d]Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China[*1]Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China[*2]Department of Dermatology, China-Japan Friendship Hospital, East Street Cherry Park, Chaoyang District, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Bao Li Zhang,Xiao Peng Zhang,Bo Zhi Chen,et al.Microneedle-assisted technology for minimally invasive medical sensing[J].MICROCHEMICAL JOURNAL.2021,162:doi:10.1016/j.microc.2020.105830.
APA：
Bao Li Zhang,Xiao Peng Zhang,Bo Zhi Chen,Wen Min Fei,Yong Cui&Xin Dong Guo.(2021).Microneedle-assisted technology for minimally invasive medical sensing.MICROCHEMICAL JOURNAL,162,
MLA：
Bao Li Zhang,et al."Microneedle-assisted technology for minimally invasive medical sensing".MICROCHEMICAL JOURNAL 162.(2021)
