单位：[1]State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, 10029, China[2]Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China[3]Department of Dermatology, China-Japan Friendship Hospital, East Street Cherry Park, Chaoyang District, Beijing, 100029, China[4]High-Tech Research Institute, Beijing University of Chemical Technology, Beijing, China
At present, microneedles have been widely used in transdermal drug delivery and detection due to their painless and non-invasive advantages, among which porous microneedles have great potential in dry or liquid drug delivery and disease monitoring due to their interoperable pore structure. However, previous literature paid little attention to the porous microneedles, and worse, most of them focused on the preparation methods of the porous microneedles used for drug delivery, while the matrix materials of porous microneedles and the potential for biomarker detection were rarely mentioned. The purpose of this review is to summarize the commonly used matrix materials for porous microneedles and highlight the ongoing challenges and prospects of their application in transdermal drug delivery and disease detection.
基金：
National Natural Science Foundation of China [51873015, 52161145410]; Joint Project of BRC-BC (Biomedical Translational Engineering Research Center of BUCT-CJFH) [XK2020-05, RZ2020-01]; Ministry of Finance; Ministry of Education of PRC
第一作者单位：[1]State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, 10029, China[2]Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China
通讯作者：
通讯机构：[1]State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, 10029, China[2]Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China[3]Department of Dermatology, China-Japan Friendship Hospital, East Street Cherry Park, Chaoyang District, Beijing, 100029, China[4]High-Tech Research Institute, Beijing University of Chemical Technology, Beijing, China[*1]Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.[*2]Department of Dermatology, China-Japan Friendship Hospital, East Street Cherry Park, Chaoyang District, Beijing, 100029, China.
推荐引用方式(GB/T 7714)：
He Yu Ting,Liang Ling,Zhao Ze Qiang,et al.Advances in porous microneedle systems for drug delivery and biomarker detection: A mini review[J].JOURNAL of DRUG DELIVERY SCIENCE and TECHNOLOGY.2022,74:doi:10.1016/j.jddst.2022.103518.
APA：
He, Yu Ting,Liang, Ling,Zhao, Ze Qiang,Hu, Liu Fu,Fei, Wen Min...&Guo, Xin Dong.(2022).Advances in porous microneedle systems for drug delivery and biomarker detection: A mini review.JOURNAL of DRUG DELIVERY SCIENCE and TECHNOLOGY,74,
MLA：
He, Yu Ting,et al."Advances in porous microneedle systems for drug delivery and biomarker detection: A mini review".JOURNAL of DRUG DELIVERY SCIENCE and TECHNOLOGY 74.(2022)
