单位：[1]Ultrasound Department, Beijing Friendship Hospital, Capital Medical University, Beijing, China医技科室影像中心超声医学科首都医科大学附属北京友谊医院[2]Ultrasound Department, Thomas Jefferson University, Philadelphia, PA, USA[3]Pathology Department, Beijing Friendship Hospital, Capital Medical University, Beijing, China医技科室病理科病理科首都医科大学附属北京友谊医院[4]Laboratory Department, Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院
Background Papillary thyroid carcinoma (PTC) is often associated with cervical lymph node metastasis (LNM), which may cause poor prognosis. Both fine-needle aspiration cytology (FNAC) and thyroglobulin measurement with fine-needle aspiration (Tg-FNA) have high diagnostic efficacy, but the diagnostic values and relationships among BRAF(v600e) mutation (BRAF(MUT)) testing, FNAC and FNA-Tg are unclear. Methods: We enrolled 145 patients with confirmed PTC and lymph nodes (LNs) that were suspected to be metastatic based on ultrasound findings, who were treated from May 2017 to April 2018, and underwent FNAC, Tg-FNA and BRAF(MUT) tests. Diagnostic efficacy was calculated by diagnostic and chi-square tests. Results: Diagnostic values were FNAC-sensitivity: 67%, specificity: 100%, PPV: 100%, NPV: 66%, accuracy: 80%; and FNA-Tg (at a cut-off of 2.23 ng/mL)-sensitivity: 97.3%, specificity: 87.8%, PPV: 87.8%, NPV: 97.3%, accuracy: 92.3%. In the BRAF(MUT+) group, sensitivities and specificities were FNAC: 68.6% and 100%, Tg-FNA: 94.4% and 85.7%; compared with FNAC: 75% and 90.9%, Tg-FNA: 80% and 100% in the BRAF(MUT-) group. Conclusion: The combination of Tg-FNA + FNAC is useful in diagnosing metastatic PTC. BRAF mutational status does not affect the diagnostic performance of FNAC or Tg-FNA.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [041320015]
第一作者单位：[1]Ultrasound Department, Beijing Friendship Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Ultrasound Department, Beijing Friendship Hospital, Capital Medical University, Beijing, China[*1]Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong’an Road, Xicheng District, Beijing, China
推荐引用方式(GB/T 7714)：
Li Jianming,Liu Jibin,Yu Xiaomeng,et al.BRAF(v600e) mutation combined with thyroglobulin and fine-needle aspiration in diagnosis of lymph node metastasis of papillary thyroid carcinoma[J].PATHOLOGY RESEARCH and PRACTICE.2018,214(11):1892-1897.doi:10.1016/j.prp.2018.09.003.
APA：
Li, Jianming,Liu, Jibin,Yu, Xiaomeng,Bao, Xiaoli&Qian, Linxue.(2018).BRAF(v600e) mutation combined with thyroglobulin and fine-needle aspiration in diagnosis of lymph node metastasis of papillary thyroid carcinoma.PATHOLOGY RESEARCH and PRACTICE,214,(11)
MLA：
Li, Jianming,et al."BRAF(v600e) mutation combined with thyroglobulin and fine-needle aspiration in diagnosis of lymph node metastasis of papillary thyroid carcinoma".PATHOLOGY RESEARCH and PRACTICE 214..11(2018):1892-1897
