单位：[1]Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China四川大学华西医院[2]Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, P.R. China
This study aimed to help clarify the possible relationships of thyroid function with intracranial arterial stenosis or carotid atheromatous plaques in ischemic stroke patients with euthyroidism. We retrospectively reviewed the medical records of a consecutive series of ischemic stroke patients prospectively entered into the Chengdu Stroke Registry between February 2010 and March2012. We performed univariate and multivariate analysis to assess possible relationships of thyroid function with intracranial artery stenosis or carotid atheromatous plaques. Of the 172 patients analyzed (42 women; 61.7 +/- 14.0 years old), 62 (32.0%) had carotid atheromatous plaques, and 81 (47.1%) had intracranial artery stenosis. Free thyroxine levels were lower in patients with carotid atheromatous plaques than in patients without plaques (15.80 +/- 2.09 vs. 16.92 +/- 2.69, P = 0.005). After adjusting for age, gender, hyperlipidemia, and previous smoking, free thyroxine levels were independently associated with carotid atheromatous plaques (OR 0.73, 95% CI 0.54-0.99, P = 0.04). In contrast, thyroid function indicators showed no associations with intracranial arterial stenosis. In conclusion, low free thyroxine levels were independently associated with carotid atheromatous plaques in ischemic stroke patients with euthyroidism, but thyroid function indicators were not associated with intracranial artery stenosis.
基金：
Science and technology infrastructure projects of Sichuan Province [2012JCPT008]; Chengdu Science and Technology Public Welfare Project [2014-HM01-00398-SF]
第一作者单位：[1]Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China
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推荐引用方式(GB/T 7714)：
Liu Junfeng,Cui Xiaoyang,Wang Deren,et al.Relationship of thyroid function with intracranial arterial stenosis and carotid atheromatous plaques in ischemic stroke patients with euthyroidism[J].ONCOTARGET.2017,8(28):46532-46539.doi:10.18632/oncotarget.14883.
APA：
Liu, Junfeng,Cui, Xiaoyang,Wang, Deren,Wu, Simiao,Xiong, Yao...&Liu, Ming.(2017).Relationship of thyroid function with intracranial arterial stenosis and carotid atheromatous plaques in ischemic stroke patients with euthyroidism.ONCOTARGET,8,(28)
MLA：
Liu, Junfeng,et al."Relationship of thyroid function with intracranial arterial stenosis and carotid atheromatous plaques in ischemic stroke patients with euthyroidism".ONCOTARGET 8..28(2017):46532-46539
医学