单位：[1]Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China北京朝阳医院[2]Department of General Surgery Department & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing 100029, China
Objective: Bariatric surgery has become the most effective treatment for morbid obesity. Increasing evidence showed that bariatric surgery can alleviate insulin resistance and influence thyroid function. This study aimed to investigate the relationship between changes in thyroid function and adipose tissue insulin resistance (adipo-IR) after bariatric surgery. Methods: A total of 287 non-diabetic participants with regular thyroid function were recruited and divided into the lean, overweight and obese groups. Among them, 50 morbidly obese patients submitted to bariatric surgery. Results: The obese group had a higher level of adipo-IR, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), FT3/free thyroxine (FT4) and metabolism disorders than the lean and overweight groups. BMI was correlated with TSH, FT3, FT3/FT4 and adipo-IR (r = 0.309, 0.315, 0.322 and 0.651, respectively, all P < 0.001). Adipo-IR was significantly correlated with TSH (r = 0.402, P < 0.001), FT3 (r = 0.309, P < 0.001), and FT3/FT4 (r = 0.228, P < 0.05). Bariatric surgery resulted in a sharp decline in BMI, adipo-IR, TSH, FT3 and FT3/FT4 levels, meanwhile, metabolic disorders imp roved. The decrease in BMI after bariatric surgery was significantly correlated with reductions in adipo-IR (r = 0.577, P < 0.001) and TSH (r = 0.401, P = 0.005). Interestingly, the fasting blood glucose, fasting insulin, adipo-IR and TSH in the higher TSH group decreased more remarkably than in the lower TSH group. Conclusion: Obese individuals with higher TSH levels had an obvious metabolic improvement after bariatric surgery.
基金：
Chinese National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81770792]; Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support [ZYL X20 2106]; Foundation of Beijing Municipal Science & Technology Commission [Z151100004015065]
第一作者单位：[1]Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
通讯作者：
通讯机构：[1]Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China[2]Department of General Surgery Department & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing 100029, China[*1]Department of Endocrinology, Beijing Chao-Yang Hospital, No. 8, Gongti South Road, Chaoyang District, Beijing 100020, P. R. of China.[*2]Department of General Surgery Department & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Yinghua Dong Street, Hepingli, Chaoyang District, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Bian Nannan,Sun Xiaomeng,Zhou Biao,et al.Obese patients with higher TSH levels had an obvious metabolic improvement after bariatric surgery[J].ENDOCRINE CONNECTIONS.2021,10(10):1326-1336.doi:10.1530/EC-21-0360.
APA：
Bian Nannan,Sun Xiaomeng,Zhou Biao,Zhang Lin,Wang Qiu...&Wang Guang.(2021).Obese patients with higher TSH levels had an obvious metabolic improvement after bariatric surgery.ENDOCRINE CONNECTIONS,10,(10)
MLA：
Bian Nannan,et al."Obese patients with higher TSH levels had an obvious metabolic improvement after bariatric surgery".ENDOCRINE CONNECTIONS 10..10(2021):1326-1336
