单位：[1]Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China北京朝阳医院[2]General Surgery Department & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China
Objective: Prolactin (PRL) is a polypeptide hormone named for its crucial role in lactation. Recently, PRL has been recognized as a metabolic hormone that regulates energy metabolism. The current study aimed to investigate the relationship between circulating PRL and metabolic alterations in overweight/obese patients and the effect of weight loss through bariatric surgery on circulating PRL. Methods: A total of 448 overweight/obese patients aged between 18 and 40 years and 120 age- and sex-matched healthy controls with normal weight were enrolled. Among all participants, 156 obese patients underwent bariatric surgery. Results: Circulating PRL levels were significantly increased in the overweight (15.27 +/- 9.58 mg/L) and obese (17.75 +/- 9.15 mg/L) groups compared with the normal weight (13.57 +/- 9.03 mg/L) group. Multiple regression analyses demonstrated that the adipose tissue insulin resistance (adipo-IR) level was an independent predictor for PRL (beta = -0.451, P <.01). Despite comparable anthropometric parameters, the overweight/obese patients with a higher PRL tertile had decreased levels of triglycerides, nonesterified fatty acids, homeostasis model assessment of insulin resistance, and adipo-IR compared with the patients in the moderate and lower PRL tertiles. Serum PRL levels were significantly decreased following the alleviation of metabolic parameters after bariatric surgery (from 17.12 +/- 8.27 to 13.00 +/- 5.78 mu g/L, P <.05), and the decrease in PRL levels was significantly greater in the lower adipo-IR group than in the higher adipo-IR group (P <.01). Conclusion: An increased serum PRL level might be an adaptive response for protecting against metabolic disorders in obesity. (C) 2021 AACE. Published by Elsevier Inc. All rights reserved.
基金：
Beijing Talents foundation [2018-12]; Capital Funds for Health Improvement and Research [2018-4-2034]; Chinese National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81770792]; Key Projects of Science and Technology Planning Of Beijing Municipal Education Commission [KZ201810025038]; Foundation of Beijing Municipal Science & Technology Commission [Z151100004015065]
第一作者单位：[1]Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China[2]General Surgery Department & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China[*1]Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China[*2]General Surgery Department & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Yinghuayuan East Street, Chaoyang District, Beijing, China, 100029
推荐引用方式(GB/T 7714)：
Liu Jia,Wang Qiu,Zhang Lin,et al.Increased Prolactin is an Adaptive Response to Protect Against Metabolic Disorders in Obesity[J].ENDOCRINE PRACTICE.2021,27(7):728-735.doi:10.1016/j.eprac.2021.01.002.
APA：
Liu Jia,Wang Qiu,Zhang Lin,Fu Jing,An Yu...&Wang Guang.(2021).Increased Prolactin is an Adaptive Response to Protect Against Metabolic Disorders in Obesity.ENDOCRINE PRACTICE,27,(7)
MLA：
Liu Jia,et al."Increased Prolactin is an Adaptive Response to Protect Against Metabolic Disorders in Obesity".ENDOCRINE PRACTICE 27..7(2021):728-735
