单位：[1]Department of Neurology, China-Japan Friendship Hospital, 2 Yinghuadong Road, Chaoyang District, Beijing 100029, China[2]Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, 9th Dong Dan San Tiao, Dongcheng District, Beijing 100730, China[3]Department of Neurobiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China
Alzheimer's disease (AD) is the most common type of dementia and has caused a major global health concern. Understanding the etiology of AD can be beneficial for the diagnosis and intervention of this disease. Genetics plays a vital role in the pathogenesis of AD. Research methods in genetics such as the linkage analysis, study of candidate genes, genome-wide association study (GWAS), and next-generation sequencing (NGS) technology help us map the genetic information in AD, which can not only provide a new insight into the pathogenesis of AD but also be beneficial for early targeted intervention of AD. This review summarizes the pathogenesis as well as the diagnostic and therapeutic value of genetics in AD. (C) 2017 Elsevier Ltd. All rights reserved.
基金：
National Key R&D Program of China [2016YFC1306300]
第一作者单位：[1]Department of Neurology, China-Japan Friendship Hospital, 2 Yinghuadong Road, Chaoyang District, Beijing 100029, China[2]Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, 9th Dong Dan San Tiao, Dongcheng District, Beijing 100730, China
通讯作者：
通讯机构：[1]Department of Neurology, China-Japan Friendship Hospital, 2 Yinghuadong Road, Chaoyang District, Beijing 100029, China[2]Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, 9th Dong Dan San Tiao, Dongcheng District, Beijing 100730, China[3]Department of Neurobiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China[*1]Department of Neurology, China-Japan Friendship Hospital, 2 Yinghuadong Road, Chaoyang District, Beijing 100029, China[*2]Department of Neurobiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Beijing Institute for Brain Disorders, Capital Medical University, 11, Beijing 100069, China
推荐引用方式(GB/T 7714)：
Shao Wen,Peng Dantao,Wang Xiaomin.Genetics of Alzheimer's disease: From pathogenesis to clinical usage[J].JOURNAL of CLINICAL NEUROSCIENCE.2017,45:1-8.doi:10.1016/j.jocn.2017.06.074.
APA：
Shao, Wen,Peng, Dantao&Wang, Xiaomin.(2017).Genetics of Alzheimer's disease: From pathogenesis to clinical usage.JOURNAL of CLINICAL NEUROSCIENCE,45,
MLA：
Shao, Wen,et al."Genetics of Alzheimer's disease: From pathogenesis to clinical usage".JOURNAL of CLINICAL NEUROSCIENCE 45.(2017):1-8
