单位：[1]Department of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Laboratory of Brain Disorders (MOST), Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China[2]Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA[3]Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China首都医科大学附属北京友谊医院[4]Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China[5]Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China[6]Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China[7]Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536, USA[8]Tianjin Anding Hospital, Tianjin 300222, China[9]Jiaxing Entry-Exit Inspection and Quarantine, Jiaxing 314001, China
POK erythroid myeloid ontogenic factor (Pokemon), an important proto-oncoprotein, is a transcriptional repressor that regulates the expression of many genes and plays an important role in tumorigenesis. Resveratrol (RSV), a natural polyphenolic compound, has many beneficial biological effects on health. In this study, we investigated the role of Pokemon in RSV-induced biological effects and the effect of RSV on the expression of Pokemon in glioma cells. We found that overexpression of Pokemon decreased RSV-induced cell apoptosis, senescence, and anti-proliferative effects. Moreover, we showed that RSV could efficiently decrease the activity of the Pokemon promoter and the expression of Pokemon. Meanwhile, RSV also inhibited Sp1 DNA binding activity to the Pokemon promoter; whereas, it did not influence the expression and nuclear translocation of Sp1. In addition, we found that RSV could increase the recruitment of HDAC1, but decreased p300 to the Pokemon promoter. Taken together, all these results extended our understanding on the anti-cancer mechanism of RSV in glioma cells.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31271154, 31171032]; National Basic Research ProgramNational Basic Research Program of China [2010CB912003]; Development Project of Science and Technology - Beijing Education Committee [KM201310025001]; Specialized Research Fund for the Doctoral Program of Higher EducationSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20111107120011]
第一作者单位：[1]Department of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Laboratory of Brain Disorders (MOST), Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China
通讯作者：
推荐引用方式(GB/T 7714)：
Yutao Yang,Jiajun Cui,Feng Xue,et al.Resveratrol Represses Pokemon Expression in Human Glioma Cells[J].MOLECULAR NEUROBIOLOGY.2016,53(2):1266-1278.doi:10.1007/s12035-014-9081-2.
APA：
Yutao Yang,Jiajun Cui,Feng Xue,Anne-Marie Overstreet,Yiping Zhan...&Zhi-Qing David Xu.(2016).Resveratrol Represses Pokemon Expression in Human Glioma Cells.MOLECULAR NEUROBIOLOGY,53,(2)
MLA：
Yutao Yang,et al."Resveratrol Represses Pokemon Expression in Human Glioma Cells".MOLECULAR NEUROBIOLOGY 53..2(2016):1266-1278
