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Staurosporine Induced Apoptosis Rapidly Downregulates TDP-43 in Glioma Cells

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单位： [1]Beijing Univ Chinese Med, Ctr Lab, Sch Preclin Med, Beijing, Peoples R China [2]China Japan Friendship Hosp, Int Med Ctr, Beijing, Peoples R China [3]Univ British Columbia, Brain Res Ctr, Vancouver, BC V5Z 1M9, Canada [4]Univ British Columbia, Dept Surg, Vancouver, BC V5Z 1M9, Canada

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关键词： Apoptosis caspase-3 glioma cells staurosporine TDP-43

摘要：

TDP-43 is a ubiquitously expressed DNA/RNA binding protein that has recently attracted attention for its involvement in neurodegenerative diseases. While TDP-43 has been found to participate in various important cellular activities including stress and apoptosis, little is known about its role in cancer cells. Here we report that staurosporine (STS) induced apoptosis in U87 glioma cells is associated with rapid downregulation of TDP-43 at both mRNA and protein levels. The latter is dependent on activation of caspase 3. More importantly, we have shown that knockdown of TDP-43 by specific siRNA dramatically enhanced cytotoxicity of STS. These results suggest that normal level of TDP-43 may be protective for cancer cells under apoptotic insult.

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出版当年[2013]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

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出版当年[2012]版：

Q4 ONCOLOGY

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影响因子： 最新[2023版] 0 最新五年平均[2021-2025] 0 出版当年[2012版] 1.271 出版当年五年平均[2008-2012] 1.334 出版前一年[2011版] 0.659 出版后一年[2013版] 1.5

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第一作者单位： [1]Beijing Univ Chinese Med, Ctr Lab, Sch Preclin Med, Beijing, Peoples R China [2]China Japan Friendship Hosp, Int Med Ctr, Beijing, Peoples R China

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