We could induce apoptosis in primary Cultures of cortical neurons of fetal mice with ceramide or sorbitol. The induction was accompanied by an increase in caspase-3 (CAS-3) activity and depolarization of the inner mitochondrial membrane of neuronal cells which both could be reversed by Herpes simplex virus I (HSV-1) infection. We conclude tha HSV-1 infection inhibited the apoptosis, induced in neuronal cells by sorbitol or ceramide, via a CAS-dependent pathway.
Wang JW,Wang DX,Wang RJ,et al.Herpes simplex virus 1 inhibits apoptosis through a caspase-3-dependent pathway in primary cultures of cortical neuronal cells of fetal mice[J].ACTA VIROLOGICA.2005,49(1):45-49.
APA：
Wang, JW,Wang, DX,Wang, RJ,Li, WR,Tuo, HZ&Feng, ZJ.(2005).Herpes simplex virus 1 inhibits apoptosis through a caspase-3-dependent pathway in primary cultures of cortical neuronal cells of fetal mice.ACTA VIROLOGICA,49,(1)
MLA：
Wang, JW,et al."Herpes simplex virus 1 inhibits apoptosis through a caspase-3-dependent pathway in primary cultures of cortical neuronal cells of fetal mice".ACTA VIROLOGICA 49..1(2005):45-49
