单位：[1]Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai[2]Guangzhou Institute of Respiratory Disease, Guangzhou[3]Department of Respiratory and Critical Care Medicine, Beijing China-Japan Friendship Hospital[4]Department of Pulmonary Medicine, Chaoyang Hospital, Beijing, People’s Republic of China北京朝阳医院
COPD is characterized by a progressive decline in lung function and mental and physical comorbidities. It is a significant burden worldwide due to its growing prevalence, comorbidities, and mortality. Complication by bronchial-pulmonary infection causes 50%-90% of acute exacerbations of COPD (AECOPD), which may lead to the aggregation of COPD symptoms and the development of acute respiratory failure. Non-invasive or invasive ventilation (IV) is usually implemented to treat acute respiratory failure. However, ventilatory support (mainly IV) should be discarded as soon as possible to prevent the onset of time-dependent complications. To withdraw IV, an optimum timing has to be selected based on weaning assessment and spontaneous breathing trial or replacement of IV by non-IV at pulmonary infection control window. The former method is more suitable for patients with AECOPD without significant bronchial-pulmonary infection while the latter method is more suitable for patients with AECOPD with acute significant bronchial-pulmonary infection.
基金：
National Key Technology R&D Program of the 12th National Five-year Development PlanNational Key Technology R&D Program [2012BAI05B01, 2012BAI05B02]; National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81170056, 81400018, 81400002]; Shanghai Committee of Science and TechnologyShanghai Science & Technology Committee [11411951102, 12JC1402300]; Academic Special Science and Research Foundation [20130071110044]
第一作者单位：[1]Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai
通讯作者：
通讯机构：[3]Department of Respiratory and Critical Care Medicine, Beijing China-Japan Friendship Hospital[*1]Department of Respiratory and Critical Care Medicine, Beijing China-Japan Friendship Hospital, 2 East Yinghua Road, Beijing, 100029, People’s Republic of China
推荐引用方式(GB/T 7714)：
Song Yuanlin,Chen Rongchang,Zhan Qingyuan,et al.The optimum timing to wean invasive ventilation for patients with AECOPD or COPD with pulmonary infection[J].INTERNATIONAL JOURNAL of CHRONIC OBSTRUCTIVE PULMONARY DISEASE.2016,11:535-541.doi:10.2147/COPD.S96541.
APA：
Song, Yuanlin,Chen, Rongchang,Zhan, Qingyuan,Chen, Shujing,Luo, Zujin...&Wang, Chen.(2016).The optimum timing to wean invasive ventilation for patients with AECOPD or COPD with pulmonary infection.INTERNATIONAL JOURNAL of CHRONIC OBSTRUCTIVE PULMONARY DISEASE,11,
MLA：
Song, Yuanlin,et al."The optimum timing to wean invasive ventilation for patients with AECOPD or COPD with pulmonary infection".INTERNATIONAL JOURNAL of CHRONIC OBSTRUCTIVE PULMONARY DISEASE 11.(2016):535-541
