Objective: The study revealed how Recuperating Lung Decoction (RLD) intervenes in asthma on the basis of successful construction of rabbit asthma model and the effective evaluation guided by Traditional Chinese Medicine (TCM) theory and metabolomics. Materials and methods: 21rabbits were randomly divided into three groups: blank control group, model group, treatment group; in 14 of them, the asthma model was established. The rabbits in the treatment group was treated orally with RLD. The rats in the normal and model groups were given 0.9% saline. Metabolites were compared among the groups, which were determined by Gas chromatography-mass spectrometry (GC-MS) methods. Data was analyzed using SAS 8.0. Results: A total of 7 kinds of metabolites were detected from the Broncho alveolar lavage fluid (BALF) of rabbits, and 4 kinds of metabolites were significant after statistic comparison. The content of some metabolites changed in the model group and treatment group compared with the control group. It could be inferred that the changing was affected by modeling and drug treatment. The increased content of glycine, aspartate and galactose as well as decreased content of myristic acid were closely related to the inflammatory process in bronchial asthma. These 4 metabolites' levels obviously changed after treatment with Recuperating Lung Decoction. Conclusion: The study has developed a new Recuperating Lung Decoction intervention model in metabolomic changes of asthma in animal model, and has important theoretical and practical significance with reference to clinical and basic TCM theory.