单位：[1]Beijing University of Chinese Medicine, Beijing 100029, China[2]Second Department of TCM Pulmonary Disease, The Key Institute of State Administration of Traditional Chinese Medicine (pneumonopathy chronic cough and dyspnea), Beijing Key Laboratory (NO. BZ0321), China-Japan Friendship Hospital, Beijing 100029, China[3]State Key Laboratory for Infectious Diseases Prevention and Control, and National Institute for Communicable Disease Control and Prevention, Beijing 102206, China, Chinese Center for Disease Control and Prevention. Collaborative Innovation Center Diagnosis and Treatment of Infectious Disease, Hangzhou 310003, Zhejiang, China[4]Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China[5]Nephrology Department, Aviation General Hospital of China Medical University, Beijing 100012, China
Objective To investigate whether recuperating lung decoction (RLD) can modulate the composition of gut microbiota in rats during asthma treatment. Methods Fifteen Sprague-Dawley rats were divided randomly and equally into control group, model group, dexamethasone (DEX) group, RLD medium-dose group, and RLD high-dose group. The asthma model was established in all groups, except for the control group. The rats in the DEX and RLD groups were treated orally with DEX and RLD, respectively. The rats in the control and model groups were treated orally with 0.9% saline. The intestinal bacterial communities were compared among groups using 16S rRNA gene amplification and 454 pyrosequencing. Results The microbial flora differed between the control and model groups, but the flora in the RLD groups was similar to that in the control group. No significant differences were observed between the RLD high-dose and medium-dose groups. RLD treatment resulted in an increase in the level beneficial bacteria in the gut, such as Lactobacillus and Bifidobacterium spp. Conclusion Oral administration of RLD increased the number of intestinal lactic acid-producing bacteria, such as Lactobacillus and Bifidobacterium, in asthma model rats.
基金：
Young Scientists Fund of National Science Foundation of China [81302943, 81302941]; project aimed at promoting the talents of young scientists [2015-QNYC-A-01]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区环境科学与生态学
小类|4 区环境科学4 区公共卫生、环境卫生与职业卫生
最新[2025]版：
大类|4 区医学
小类|4 区环境科学4 区公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2014]版：
Q2ENVIRONMENTAL SCIENCESQ2PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
最新[2023]版：
Q2ENVIRONMENTAL SCIENCESQ2PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
第一作者单位：[1]Beijing University of Chinese Medicine, Beijing 100029, China
共同第一作者：
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推荐引用方式(GB/T 7714)：
KONG Yan Hua,SHI Qi,HAN Na,et al.Structural Modulation of Gut Microbiota in Rats with Allergic Bronchial Asthma Treated with Recuperating Lung Decoction[J].BIOMEDICAL and ENVIRONMENTAL SCIENCES.2016,29(8):574-583.doi:10.3967/bes2016.076.
APA：
KONG Yan Hua,SHI Qi,HAN Na,ZHANG Ling,ZHANG Yuan Yuan...&LI You Lin.(2016).Structural Modulation of Gut Microbiota in Rats with Allergic Bronchial Asthma Treated with Recuperating Lung Decoction.BIOMEDICAL and ENVIRONMENTAL SCIENCES,29,(8)
MLA：
KONG Yan Hua,et al."Structural Modulation of Gut Microbiota in Rats with Allergic Bronchial Asthma Treated with Recuperating Lung Decoction".BIOMEDICAL and ENVIRONMENTAL SCIENCES 29..8(2016):574-583
