单位：[1]Cardiovascular Research Institute, University of California, San Francisco[2]Division of Cardiology, University of California, San Francisco[3]Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco[4]Division of Occupational and Environmental Medicine (S.F.S.), University of California, San Francisco[5]Department of Cardiovascular Surgery & Electro-chemotherapy, China-Japan Friendship Hospital, Beijing, People’s Republic of China[6]Drexel University College of Medicine, Philadelphia, PA.[7]located at Albany Medical College, Albany, NY.[8]located at Rush Medical College, Chicago, IL.
Background-Despite public awareness that tobacco secondhand smoke (SHS) is harmful, many people still assume that marijuana SHS is benign. Debates about whether smoke-free laws should include marijuana are becoming increasingly widespread as marijuana is legalized and the cannabis industry grows. Lack of evidence for marijuana SHS causing acute cardiovascular harm is frequently mistaken for evidence that it is harmless, despite chemical and physical similarity between marijuana and tobacco smoke. We investigated whether brief exposure to marijuana SHS causes acute vascular endothelial dysfunction. Methods and Results-We measured endothelial function as femoral artery flow-mediated dilation (FMD) in rats before and after exposure to marijuana SHS at levels similar to real-world tobacco SHS conditions. One minute of exposure to marijuana SHS impaired FMD to a comparable extent as impairment from equal concentrations of tobacco SHS, but recovery was considerably slower for marijuana. Exposure to marijuana SHS directly caused cannabinoid-independent vasodilation that subsided within 25 minutes, whereas FMD remained impaired for at least 90 minutes. Impairment occurred even when marijuana lacked cannabinoids and rolling paper was omitted. Endothelium-independent vasodilation by nitroglycerin administration was not impaired. FMD was not impaired by exposure to chamber air. Conclusions-One minute of exposure to marijuana SHS substantially impairs endothelial function in rats for at least 90 minutes, considerably longer than comparable impairment by tobacco SHS. Impairment of FMD does not require cannabinoids, nicotine, or rolling paper smoke. Our findings in rats suggest that SHS can exert similar adverse cardiovascular effects regardless of whether it is from tobacco or marijuana.
基金：
NIH National Institute on Drug AbuseUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Drug Abuse (NIDA) [R21DA031966]; Elfenworks Foundation; NATIONAL INSTITUTE ON DRUG ABUSEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Drug Abuse (NIDA)European Commission [R21DA031966] Funding Source: NIH RePORTER
第一作者单位：[1]Cardiovascular Research Institute, University of California, San Francisco
通讯作者：
通讯机构：[1]Cardiovascular Research Institute, University of California, San Francisco[2]Division of Cardiology, University of California, San Francisco[3]Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco[*1]Division of Cardiology, University of California, San Francisco, 513 Parnassus Ave, Box 0124, San Francisco, CA 94143
推荐引用方式(GB/T 7714)：
Wang Xiaoyin,Derakhshandeh Ronak,Liu Jiangtao,et al.One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function[J].JOURNAL of the AMERICAN HEART ASSOCIATION.2016,5(8):doi:10.1161/JAHA.116.003858.
APA：
Wang, Xiaoyin,Derakhshandeh, Ronak,Liu, Jiangtao,Narayan, Shilpa,Nabavizadeh, Pooneh...&Springer, Matthew L..(2016).One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function.JOURNAL of the AMERICAN HEART ASSOCIATION,5,(8)
MLA：
Wang, Xiaoyin,et al."One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function".JOURNAL of the AMERICAN HEART ASSOCIATION 5..8(2016)
医学