The prognostic significance of human epidermal growth factor receptor family protein expression in operable pancreatic cancer HER1-4 protein expression and prognosis in pancreatic cancer
单位：[1]Department of Oncology, Beijing Friendship Hospital, Capital MedicalUniversity, Beijing 100050, China临床科室肿瘤中心肿瘤内科首都医科大学附属北京友谊医院[2]Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, China医技科室病理科病理科首都医科大学附属北京友谊医院[3]Research Experiments Center, Beijing Friendship Hospital, Capital Medical University,Beijing, China首都医科大学附属北京友谊医院[4]Department of Biochemistry and Molecular Biology, BasicMedical College, Shanxi Medical University, Taiyuan, China[5]Department of Pathology and Pathophysiology, Basic Medical College, Capital MedicalUniversity, Beijing, China[6]Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University,Beijing, China临床科室国家中心消化分中心首都医科大学附属北京友谊医院
Background: Prognostic factors aid in the stratification and treatment of cancer. This study evaluated the prognostic significance of human epidermal growth factor receptor (HER) family members (HER1-4) expression in patients with operable pancreatic cancer. Methods: The expression of individual HER proteins in patient tissue specimens was detected by immunohistochemistry staining. Patient follow-up time was between 1.0 and 78.1 months. Results: Positive expression of HER1, HER2, HER3 and HER4 was detected in 41.4, 60.0, 24.3 and 65.7% of cases, respectively. Kaplan-Meier analysis revealed that HER3 positive expression was associated with decreased median survival time (12.0 vs. 25.6 months for HER3 positive and negative groups, respectively; P = 0.013). Cox's regression confirmed that positive HER3 expression was an independent predictor of poor survival (RR = 3.684, P = 0.001). In contrast, HER4 negative patients had a significantly decreased median survival time when compared with HER4 positive patients (11.4 vs. 25. 6 months, respectively; P = 0.027). However, HER4 was not an independent predictor of survival. No significant association between HER1 or HER2 expression and survival was observed (P = 0.626 & P = 0.859, respectively). Conclusions: HER3 is an independent prognostic marker for patients with operable pancreatic cancer. HER4 may also be of potential prognostic value in this disease and deserves further attention.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81301912, 81272615]; Beijing Municipal Health System High-level Health Person Foundation Project [2014-3-005]; Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission; Capital Health Research and Development Project
第一作者单位：[1]Department of Oncology, Beijing Friendship Hospital, Capital MedicalUniversity, Beijing 100050, China
通讯作者：
通讯机构：[1]Department of Oncology, Beijing Friendship Hospital, Capital MedicalUniversity, Beijing 100050, China[6]Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University,Beijing, China
推荐引用方式(GB/T 7714)：
Li Qin,Zhang Lei,Li XiuHong,et al.The prognostic significance of human epidermal growth factor receptor family protein expression in operable pancreatic cancer HER1-4 protein expression and prognosis in pancreatic cancer[J].BMC CANCER.2016,16:doi:10.1186/s12885-016-2889-6.
APA：
Li, Qin,Zhang, Lei,Li, XiuHong,Yan, Han,Yang, Liuting...&Cao, Bangwei.(2016).The prognostic significance of human epidermal growth factor receptor family protein expression in operable pancreatic cancer HER1-4 protein expression and prognosis in pancreatic cancer.BMC CANCER,16,
MLA：
Li, Qin,et al."The prognostic significance of human epidermal growth factor receptor family protein expression in operable pancreatic cancer HER1-4 protein expression and prognosis in pancreatic cancer".BMC CANCER 16.(2016)
